9.A.3.1.2
The multicomponent Retriever-CCC-WASH Complex (formerly called the PDZ domain-containing SNX31-retromer assembly apparatus). The CCC and WASH complexes appear to function in recruitment to the endosomes. Direct cargo binding may be mediated by the COMMDs (McNally and Cullen 2018). The structure of the membrane-assembled retromer coat has been determined by cryo-electron tomography (Kovtun et al. 2018) (see family description). These two complexes and their functions have been reviewed (Chen et al. 2019).
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| Accession Number: | Q2M389 |
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| Protein Name: | WASH complex subunit 4 |
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| Length: | 1173 |
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| Molecular Weight: | 136403.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Early endosome1 |
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| Substrate |
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1: MAVETLSPDW EFDRVDDGSQ KIHAEVQLKN YGKFLEEYTS QLRRIEDALD DSIGDVWDFN
61: LDPIALKLLP YEQSSLLELI KTENKVLNKV ITVYAALCCE IKKLKYEAET KFYNGLLFYG
121: EGATDASMVE GDCQIQMGRF ISFLQELSCF VTRCYEVVMN VVHQLAALYI SNKIAPKIIE
181: TTGVHFQTMY EHLGELLTVL LTLDEIIDNH ITLKDHWTMY KRLLKSVHHN PSKFGIQEEK
241: LKPFEKFLLK LEGQLLDGMI FQACIEQQFD SLNGGVSVSK NSTFAEEFAH SIRSIFANVE
301: AKLGEPSEID QRDKYVGICG LFVLHFQIFR TIDKKFYKSL LDICKKVPAI TLTANIIWFP
361: DNFLIQKIPA AAKLLDRKSL QAIKIHRDTF LQQKAQSLTK DVQSYYVFVS SWMMKMESIL
421: SKEQRMDKFA EDLTNRCNVF IQGFLYAYSI STIIKTTMNL YMSMQKPMTK TSVKALCRLV
481: ELLKAIEHMF YRRSMVVADS VSHITQHLQH QALHSISVAK KRVISDKKYS EQRLDVLSAL
541: VLAENTLNGP STKQRRLIVS LALSVGTQMK TFKDEELFPL QVVMKKLDLI SELRERVQTQ
601: CDCCFLYWHR AVFPIYLDDV YENAVDAARL HYMFSALRDC VPAMMHARHL ESYEILLDCY
661: DKEIMEILNE HLLDKLCKEI EKDLRLSVHT HLKLDDRNPF KVGMKDLALF FSLNPIRFFN
721: RFIDIRAYVT HYLDKTFYNL TTVALHDWAT YSEMRNLATQ RYGLVMTEAH LPSQTLEQGL
781: DVLEIMRNIH IFVSRYLYNL NNQIFIERTS NNKHLNTINI RHIANSIRTH GTGIMNTTVN
841: FTYQFLKKKF YIFSQFMYDE HIKSRLIKDI RFFREIKDQN DHKYPFDRAE KFNRGIRKLG
901: VTPEGQSYLD QFRQLISQIG NAMGYVRMIR SGGLHCSSNA IRFVPDLEDI VNFEELVKEE
961: GLAEETLKAA RHLDSVLSDH TRNSAEGTEY FKMLVDVFAP EFRRPKNIHL RNFYIIVPPL
1021: TLNFVEHSIS CKEKLNKKNK IGAAFTDDGF AMGVAYILKL LDQYREFDSL HWFQSVREKY
1081: LKEIRAVAKQ QNVQSASQDE KLLQTMNLTQ KRLDVYLQEF ELLYFSLSSA RIFFRADKTA
1141: AEENQEKKEK EEETKTSNGD LSDSTVSADP VVK