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3.D.7.1.1
H2:heterodisulfide oxidoreductase, HHO. Two protons are consumed in the cytoplasm while two protons are released in the periplasm, contributing to the pmf (Simon et al., 2008; Welte and Deppenmeier 2013).  The HdrD/E-type heterodisulfide reductase probably can function independently of the other subunits.

Accession Number:Q50248
Protein Name:VHOG
Length:383
Molecular Weight:41068.00
Species:Methanosarcina mazei (Methanosarcina frisia) [2209]
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate hydron

Cross database links:

Pfam: PF01058   

Gene Ontology

GO:0009375 C:ferredoxin hydrogenase complex
GO:0051539 F:4 iron, 4 sulfur cluster binding
GO:0008901 F:ferredoxin hydrogenase activity
GO:0008137 F:NADH dehydrogenase (ubiquinone) activity
GO:0048038 F:quinone binding
GO:0055114 P:oxidation reduction

References (1)

[1] “Analysis of the vhoGAC and vhtGAC operons from Methanosarcina mazei strain Go1, both encoding a membrane-bound hydrogenase and a cytochrome b.”  Deppenmeier U.et.al.   7851393

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MSTGTTNLVR TLDSMDFLKM DRRTFMKAVS ALGATAFLGT YQTEIVNALE FAETKVIWIH 
61:	GSECTGCSES VLNGGNPDIV QALTKLNVNL AYHETLCMQQ GIWNDGELVN TSELNSEILL 
121:	EDLYKEGNYI LVVEGSIPNG PDGSGRYLVI GNKTFKETLG EAAKNANAIV AVGACACWGG 
181:	ITSADSDIEK DTDYRGVAFK KTDASKGMLK ELGIDKPVIN IPGCPCHPDW VLLTLGAVIL 
241:	GKIKIPDDLP AALDQYGRPK VFFPPDHTVH ENCPRRGYYD RGEFDTEVGG EKCLWKLGCK 
301:	APYAHADCGI RRWNGSVSMC TQAGGPCINC VDPGFPDASR PLYVEAEDKG IVGANIDTIA 
361:	KVAVGAAAVA AGVHAVRRMG KGE