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3.D.7.1.1
H2:heterodisulfide oxidoreductase, HHO. Two protons are consumed in the cytoplasm while two protons are released in the periplasm, contributing to the pmf (Simon et al., 2008; Welte and Deppenmeier 2013).  The HdrD/E-type heterodisulfide reductase probably can function independently of the other subunits.

Accession Number:Q50249
Protein Name:VHOA
Length:591
Molecular Weight:64147.00
Species:Methanosarcina mazei (Methanosarcina frisia) [2209]
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate hydron

Cross database links:

Pfam: PF00374   

Gene Ontology

GO:0008901 F:ferredoxin hydrogenase activity
GO:0016151 F:nickel ion binding
GO:0055114 P:oxidation reduction

References (1)

[1] “Analysis of the vhoGAC and vhtGAC operons from Methanosarcina mazei strain Go1, both encoding a membrane-bound hydrogenase and a cytochrome b.”  Deppenmeier U.et.al.   7851393

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MVNVTVDPLT RIEGHQRIST EVDANGVITD AQSSSLIFRG FERILQHQDP RDAAFLTQRI 
61:	CGVCPLSHGL TATNALDELY GVAEHVPKDA LVMRNIFQGL NMAASHATHI YVLWAPDLAN 
121:	PAYKKVLTPL GDTGNAVWDE MLGRFAPISY KMDGVPIPAG SSYLAAIPEK KRLQEMIALI 
181:	AGRMPGPSAL YPGGYTYPAT VADITKLSTY YLQIMDFISA HTLRVPFDTW IENTYKASSP 
241:	TKAVSFVTEH LTDLINKSTT SNDFSKEAGW GDTEFVPAFG SELVGEKLLG LPASLKHDTI 
301:	GGYQDPSKIC FVAYGGYYKP TDGYDPRSPA GDRIFTSGVV SGNLEYLKFG PDKITESTAH 
361:	SFYQNSVNDL PPVKGETVPF TDPEKIVYTG GSDSQYSWDK APRYDGIAGE VGPLARMLNI 
421:	KEPLVTGLAL ALAENGYSPA NVYTRMLARI QETAILAYEL LNWVTVDYEP GGKISVPLDF 
481:	NAAKDSQGMG LWEAPRGALG HWISTNGSGK VANYQCIVPG SWLMSPRDSN GIPGPLEQSL 
541:	IGSKINPVGE VDYTNPVGIF HMGRSYDPCI SCAVHTIDLT GKCAPNTLRI L