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3.D.7.1.1
H2:heterodisulfide oxidoreductase, HHO. Two protons are consumed in the cytoplasm while two protons are released in the periplasm, contributing to the pmf (Simon et al., 2008; Welte and Deppenmeier 2013).  The HdrD/E-type heterodisulfide reductase probably can function independently of the other subunits.

Accession Number:Q50250
Protein Name:VHOC aka MM2312
Length:271
Molecular Weight:31360.00
Species:Methanosarcina mazei (Methanosarcina frisia) [2209]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate hydron

Cross database links:

RefSeq: NP_634336.1   
Entrez Gene ID: 1480654   
BioCyc: MetaCyc:MONOMER-12221    MMAZ192952:MM2312-MONOMER   
KEGG: mma:MM_2312   

Gene Ontology

GO:0016020 C:membrane
GO:0016491 F:oxidoreductase activity
GO:0022904 P:respiratory electron transport chain

References (2)

[1] “Analysis of the vhoGAC and vhtGAC operons from Methanosarcina mazei strain Go1, both encoding a membrane-bound hydrogenase and a cytochrome b.”  Deppenmeier U.et.al.   7851393
[2] “The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea.”  Deppenmeier U.et.al.   12125824

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKSNNNPKAM VVERYTITDR IAHTVHAIAM IVLIITGLKI YAGWEFMSFH TARTLHMIAV 
61:	PFLLAVNWIL IPYNIFSEGH GLMGKISHFT DHYIFGPKDA VRLGGIIKNF FRKGRYPAYS 
121:	IYDEEKGHYE TKLHPVMKVL IVLEGTALFL ITVSGIVLYK LDWSLFGLPI AQWIISISGM 
181:	IAPTFGMTPV GFLRLLHLLM TYWFIFELVV HVGILGFDPH VWKYYKAIFW SGKEDFSDPY 
241:	YSEYVEKYSR FDAKKEHKQV NANKEHGHQK H