3.A.27.1.1
ER membrane protein insertase complex of ten recognized proteins, EMC1 - 10 (Guna et al. 2018). Inserts C-terminal moderately hydrophobic TMSs of tail anchored (TA) proteins into the endoplasmic reticular membrane (Guna et al. 2018). EMC also inserts the first N-terminal TMS of G-proteins and some receptors co-translationally and cooperates with the Sec61 translocon to ensure accurate topogenesis of many membrane proteins (Chitwood et al. 2018). Disrupted ER membrane protein complex-mediated topogenesis drives congenital neural crest defects (Marquez et al. 2020). The high resolution 3-d structure of this EMC complex has been determined (O'Donnell et al. 2020). EMC10 plays a regulatory role in the ER membrane complex, opposing the transmembrane-domain insertion activity of the complex (Coukos et al. 2021).
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| Accession Number: | Q8N766 |
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| Protein Name: | ER membrane protein complex subunit 1 |
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| Length: | 993 |
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| Molecular Weight: | 111759.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Single-pass type I membrane protein2 |
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| Substrate |
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1: MAAEWASRFW LWATLLIPAA AVYEDQVGKF DWRQQYVGKV KFASLEFSPG SKKLVVATEK
61: NVIAALNSRT GEILWRHVDK GTAEGAVDAM LLHGQDVITV SNGGRIMRSW ETNIGGLNWE
121: ITLDSGSFQA LGLVGLQESV RYIAVLKKTT LALHHLSSGH LKWVEHLPES DSIHYQMVYS
181: YGSGVVWALG VVPFSHVNIV KFNVEDGEIV QQVRVSTPWL QHLSGACGVV DEAVLVCPDP
241: SSRSLQTLAL ETEWELRQIP LQSLDLEFGS GFQPRVLPTQ PNPVDASRAQ FFLHLSPSHY
301: ALLQYHYGTL SLLKNFPQTA LVSFATTGEK TVAAVMACRN EVQKSSSSED GSMGSFSEKS
361: SSKDSLACFN QTYTINLYLV ETGRRLLDTT ITFSLEQSGT RPERLYIQVF LKKDDSVGYR
421: ALVQTEDHLL LFLQQLAGKV VLWSREESLA EVVCLEMVDL PLTGAQAELE GEFGKKADGL
481: LGMFLKRLSS QLILLQAWTS HLWKMFYDAR KPRSQIKNEI NIDTLARDEF NLQKMMVMVT
541: ASGKLFGIES SSGTILWKQY LPNVKPDSSF KLMVQRTTAH FPHPPQCTLL VKDKESGMSS
601: LYVFNPIFGK WSQVAPPVLK RPILQSLLLP VMDQDYAKVL LLIDDEYKVT AFPATRNVLR
661: QLHELAPSIF FYLVDAEQGR LCGYRLRKDL TTELSWELTI PPEVQRIVKV KGKRSSEHVH
721: SQGRVMGDRS VLYKSLNPNL LAVVTESTDA HHERTFIGIF LIDGVTGRII HSSVQKKAKG
781: PVHIVHSENW VVYQYWNTKA RRNEFTVLEL YEGTEQYNAT AFSSLDRPQL PQVLQQSYIF
841: PSSISAMEAT ITERGITSRH LLIGLPSGAI LSLPKALLDP RRPEIPTEQS REENLIPYSP
901: DVQIHAERFI NYNQTVSRMR GIYTAPSGLE STCLVVAYGL DIYQTRVYPS KQFDVLKDDY
961: DYVLISSVLF GLVFATMITK RLAQVKLLNR AWR