9.A.3.1.2
The multicomponent Retriever-CCC-WASH Complex (formerly called the PDZ domain-containing SNX31-retromer assembly apparatus). The CCC and WASH complexes appear to function in recruitment to the endosomes. Direct cargo binding may be mediated by the COMMDs (McNally and Cullen 2018). The structure of the membrane-assembled retromer coat has been determined by cryo-electron tomography (Kovtun et al. 2018) (see family description). These two complexes and their functions have been reviewed (Chen et al. 2019).
|
| Accession Number: | Q8N9S9 |
|---|
| Protein Name: | Sorting nexin-31 |
|---|
| Length: | 440 |
|---|
| Molecular Weight: | 50802.00 |
|---|
| Species: | Homo sapiens (Human) [9606] |
|---|
| Substrate |
|
|---|
1: MKMHFCIPVS QQRSDALGGR YVLYSVHLDG FLFCRVRYSQ LHGWNEQLRR VFGNCLPPFP
61: PKYYLAMTTA MADERRDQLE QYLQNVTMDP NVLRSDVFVE FLKLAQLNTF DIATKKAYLD
121: IFLPNEQSIR IEIITSDTAE RVLEVVSHKI GLCRELLGYF GLFLIRFGKE GKLSVVKKLA
181: DFELPYVSLG SSEVENCKVG LRKWYMAPSL DSVLMDCRVA VDLLYMQAIQ DIEKGWAKPT
241: QAQRQKLEAF QKEDSQTKFL ELAREVRHYG YLQLDPCTCD YPESGSGAVL SVGNNEISCC
301: ITLPDSQTQD IVFQMSRVKC WQVTFLGTLL DTDGPQRTLN QNLELRFQYS EDSCWQWFVI
361: YTKQAFLLSS CLKKMISEKM VKLAAENTEM QIEVPEQSKS KKYHIQQSQQ KDYSSFLSRK
421: SKIKIAKDDC VFGNIKEEDL