9.A.3.1.1
The PDZ domain-containing SNX27-retromer assembly apparatus together with the retromer subunit, ANKRD50 (Kvainickas et al. 2016). Retromer subunits include VPS26A/B (327 and 336 aas, respectively) (also cargo binding proteins) VPS35 (MEM3; 796 aas) and VPS29 (DC7, DC15; 182 aas). SNX3 (162 aas) and Rab7A (207 aas) mediate recruitment to endosomes, but SNX3 is also a cargo adaptor (McNally and Cullen 2018). Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation (Del Puerto et al. 2021).
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| Accession Number: | Q96L92 |
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| Protein Name: | Sorting nexin-27 |
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| Length: | 541 |
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| Molecular Weight: | 61265.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
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| Substrate |
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1: MADEDGEGIH PSAPHRNGGG GGGGGSGLHC AGNGGGGGGG PRVVRIVKSE SGYGFNVRGQ
61: VSEGGQLRSI NGELYAPLQH VSAVLPGGAA DRAGVRKGDR ILEVNHVNVE GATHKQVVDL
121: IRAGEKELIL TVLSVPPHEA DNLDPSDDSL GQSFYDYTEK QAVPISVPRY KHVEQNGEKF
181: VVYNVYMAGR QLCSKRYREF AILHQNLKRE FANFTFPRLP GKWPFSLSEQ QLDARRRGLE
241: EYLEKVCSIR VIGESDIMQE FLSESDENYN GVSDVELRVA LPDGTTVTVR VKKNSTTDQV
301: YQAIAAKVGM DSTTVNYFAL FEVISHSFVR KLAPNEFPHK LYIQNYTSAV PGTCLTIRKW
361: LFTTEEEILL NDNDLAVTYF FHQAVDDVKK GYIKAEEKSY QLQKLYEQRK MVMYLNMLRT
421: CEGYNEIIFP HCACDSRRKG HVITAISITH FKLHACTEEG QLENQVIAFE WDEMQRWDTD
481: EEGMAFCFEY ARGEKKPRWV KIFTPYFNYM HECFERVFCE LKWRKENIFQ MARSQQRDVA
541: T