TCDB is operated by the Saier Lab Bioinformatics Group
« See all members of the family


3.A.16.1.4
ERAD-L retrotranslocon system. SEL1L-dependent substrates require Derlin2/3 and Herp1/2 regardless of their soluble or transmembrane nature. The ERAD-L substrates take several routes to the cytosol. The HRD1-engaged route 1 requires SEL1L, Derlin2 or Derlin3, and Herp1 or Herp2 (Sugimoto et al. 2017). The nucleotide exchange factor, Grp170, a homolog of HSP70 proteins, plays a role in this ERAD pathway (Inoue and Tsai 2016).

Accession Number:Q96Q80
Protein Name:Derlin-3
Length:235
Molecular Weight:26679.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Endoplasmic reticulum membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MAWQGLAAEF LQVPAVTRAY TAACVLTTAA VQLELLSPFQ LYFNPHLVFR KFQVWRLVTN 
61:	FLFFGPLGFS FFFNMLFVFR YCRMLEEGSF RGRTADFVFM FLFGGVLMTL LGLLGSLFFL 
121:	GQALMAMLVY VWSRRSPRVR VNFFGLLTFQ APFLPWALMG FSLLLGNSIL VDLLGIAVGH 
181:	IYYFLEDVFP NQPGGKRLLQ TPGFLKLLLD APAEDPNYLP LPEEQPGPHL PPPQQ