9.A.64.1.1
The SRP-independent protein to endoplasmic reticulum insertion SND complex, Snd1(877 aas and 0 TMSs), Snd2 (181 aas and 4 TMSs; TMEM208; see 9.B.26) and Snd3 (188 aas and 2 or 3 TMSs). These proteins probably function in an SRP (signal
recognition particle)- and GET (guided entry of tail-anchored proteins)-independent pathway for targeting a broad range of substrate proteins to
the endoplasmic reticulum. The SND pathway functions in parallel to GET in
targeting proteins with downstream hydrophobic motifs (Aviram et al. 2016).
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| Accession Number: | Q99382 |
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| Protein Name: | SRP-independent targeting protein 2 |
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| Length: | 181 |
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| Molecular Weight: | 20742.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Number of TMSs: | 4 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
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| Substrate |
protein polypeptide chain |
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1: MAGKAGRKQA SSNAKIIQGL YKQVSLFLGM AIVRLFISRK VTIGQWIKLV ALNVPMFVAL
61: YIIVLSGKPK YDGNRVVKQG IDLNDNTNLI SYFFDLIYLS LFGNIGIIAF RTFKFWWCLL
121: LCPIYAGYKL YGLKNMFMPG AQQTQADNRS KNANEGQSKS KRQMKRERRG ETDSKIKYKY
181: R