ER membrane protein insertase complex of ten recognized proteins, EMC1 - 10 (Guna et al. 2018). Inserts C-terminal moderately hydrophobic TMSs of tail anchored (TA) proteins into the endoplasmic reticular membrane (Guna et al. 2018). EMC also inserts the first N-terminal TMS of G-proteins and some receptors co-translationally and cooperates with the Sec61 translocon to ensure accurate topogenesis of many membrane proteins (Chitwood et al. 2018). Disrupted ER membrane protein complex-mediated topogenesis drives congenital neural crest defects (Marquez et al. 2020). The high resolution 3-d structure of this EMC complex has been determined (O'Donnell et al. 2020). EMC10 plays a regulatory role in the ER membrane complex, opposing the transmembrane-domain insertion activity of the complex (Coukos et al. 2021).
|Protein Name:||ER membrane protein complex subunit 6|
|Species:||Homo sapiens (Human)  |
|Number of TMSs:||2|
|Location1 / Topology2 / Orientation3:
Membrane1 / Multi-pass membrane protein2
1: MAAVVAKREG PPFISEAAVR GNAAVLDYCR TSVSALSGAT AGILGLTGLY GFIFYLLASV
61: LLSLLLILKA GRRWNKYFKS RRPLFTGGLI GGLFTYVLFW TFLYGMVHVY