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3.A.23.1.1
Type VI secretion system (T6SS) VasA-L + Vca0107-09; + Vca0123 + Vc1416 (Pukatzki et al., 2006; Pukatzki et al., 2007). This secretion system displays antimicrobial properties (Macintyre et al., 2010).  It functions like contractile tails of phage and penetrates cells with a trimeric VgrG spike protein to which are associated PAAR repeat proteins that sharpen the tip of the spike and are released into the cytoplasm of the target cell (Shneider et al. 2013). Certain Vibrionaceae adapted their antibacterial T6SS to mediate interactions with eukaryotic hosts or predators, promoting their toxicity (Dar et al. 2018).

Accession Number:Q9KN48
Protein Name:Sigma-54 dependent transcriptional regulator
Length:530
Molecular Weight:59260.00
Species:Vibrio cholerae [666]
Location1 / Topology2 / Orientation3: Cell membrane1 / Lipid-anchor2
Substrate protein polypeptide chain, deoxyribonucleic acid

Cross database links:

RefSeq: NP_232518.1   
Entrez Gene ID: 2612409   
Pfam: PF02954    PF00158   
KEGG: vch:VCA0117   

Gene Ontology

GO:0005622 C:intracellular
GO:0005524 F:ATP binding
GO:0017111 F:nucleoside-triphosphatase activity
GO:0003700 F:transcription factor activity
GO:0008134 F:transcription factor binding
GO:0006355 P:regulation of transcription, DNA-dependent
GO:0006350 P:transcription

References (1)

[1] “DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae.”  Heidelberg J.F.et.al.   10952301

External Searches:

Analyze:

Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence
1:	MSQWLAFATQ LVGVRKSHQL ALQFVDLLTQ GLDLSDSLLL LPSSDGRLLV PHDPQRQFAW 
61:	SVTDFDVPFA HVLQSSNAMH LTAEELVFWQ SNRTFSQLTS RVGMFDSVWI QPLPMDTRQV 
121:	HSILLLMGES HGIVSAFENA DFLKFIEVFS QQWSLLNDME REEQRRLELK QSLTDIERDS 
181:	AQRSLANALS RTLIGESAAM QKLREQIVSA ANSQLSVMVQ GETGTGKELV AAAVHELSSR 
241:	KSAPFVAINC AAIPEHLLES ELFGYCKGAF SGADSDKQGL IAQANGGTLF LDEIGDMPLT 
301:	LQAKLLRVLE SRTFRPLGGK QELSSDFRLV SATHVNLLDQ VRKKEFRQDL YYRLFQYPIT 
361:	LPRLAARLED IELLSEHFVR VFNLQHNTRI RGLNYRAIDC LKQYDFPGNV RELKHLIEFG 
421:	CAQTADGTQV EASCFAHRLQ TLPCLAPEAT PVAVSVETEN VDLEPSVALA GEPNFAVIHD 
481:	LKQAVSQFEA LIISERLNRF AGDRAKAAKS LGIPKRTLAY KCLKLEIKTP