9.A.3.1.2 The multicomponent Retriever-CCC-WASH Complex (formerly called the PDZ domain-containing SNX31-retromer assembly apparatus). The CCC and WASH complexes appear to function in recruitment to the endosomes. Direct cargo binding may be mediated by the COMMDs (McNally and Cullen 2018). The structure of the membrane-assembled retromer coat has been determined by cryo-electron tomography (Kovtun et al. 2018) (see family description). These two complexes and their functions have been reviewed (Chen et al. 2019).
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Accession Number: | Q9UBQ0 |
Protein Name: | Vacuolar protein sorting-associated protein 29 |
Length: | 182 |
Molecular Weight: | 20506.00 |
Species: | Homo sapiens (Human) [9606] |
Location1 / Topology2 / Orientation3: |
Cytoplasm1 |
Substrate |
|
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1: MLVLVLGDLH IPHRCNSLPA KFKKLLVPGK IQHILCTGNL CTKESYDYLK TLAGDVHIVR
61: GDFDENLNYP EQKVVTVGQF KIGLIHGHQV IPWGDMASLA LLQRQFDVDI LISGHTHKFE
121: AFEHENKFYI NPGSATGAYN ALETNIIPSF VLMDIQASTV VTYVYQLIGD DVKVERIEYK
181: KP