9.A.3.1.1
The PDZ domain-containing SNX27-retromer assembly apparatus together with the retromer subunit, ANKRD50 (Kvainickas et al. 2016). Retromer subunits include VPS26A/B (327 and 336 aas, respectively) (also cargo binding proteins) VPS35 (MEM3; 796 aas) and VPS29 (DC7, DC15; 182 aas). SNX3 (162 aas) and Rab7A (207 aas) mediate recruitment to endosomes, but SNX3 is also a cargo adaptor (McNally and Cullen 2018). Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation (Del Puerto et al. 2021).
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| Accession Number: | Q9ULJ7 |
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| Protein Name: | Ankyrin repeat domain-containing protein 50 |
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| Length: | 1429 |
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| Molecular Weight: | 155859.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Endosome1 |
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| Substrate |
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1: MTNPWEEKVC KMAQTSLLQG KQFYCREWVF HKLQHCLQEK SNCCNSAVNA PSLVMNSGNN
61: ASGVSGKGAA WGVLLVGGPG SGKTALCTEL LWPSSPASLQ RGLHRQALAF HFCKAQDSDT
121: LCVGGFIRGL VAQICRSGLL QGYEDKLRDP AVQSLLQPGE CERNPAEAFK RCVLLPLLGM
181: KPPQQSLYLL VDSVDEGCNI TEGEQTSTSL SGTVAALLAG HHEFFPPWLL LLCSARKQSK
241: AVTKMFTGFR KISLDDLRKA YIVKDVQQYI LHRLDQEEAL RQHLTKETAE MLNQLHIKSS
301: GCFLYLERVL DGVVENFIML REIRDIPGTL NGLYLWLCQR LFVRKQFAKV QPILNVILAA
361: CRPLTITELY HAVWTKNMSL TLEDFQRKLD ILSKLLVDGL GNTKILFHYS FAEWLLDVKH
421: CTQKYLCNAA EGHRMLAMSY TCQAKNLTPL EAQEFALHLI NSNLQLETAE LALWMIWNGT
481: PVRDSLSTLI PKEQEVLQLL VKAGAHVNSE DDRTSCIVRQ ALEREDSIRT LLDNGASVNQ
541: CDSNGRTLLA NAAYSGSLDV VNLLVSRGAD LEIEDAHGHT PLTLAARQGH TKVVNCLIGC
601: GANINHTDQD GWTALRSAAW GGHTEVVSAL LYAGVKVDCA DADSRTALRA AAWGGHEDIV
661: LNLLQHGAEV NKADNEGRTA LIAAAYMGHR EIVEHLLDHG AEVNHEDVDG RTALSVAALC
721: VPASKGHASV VSLLIDRGAE VDHCDKDGMT PLLVAAYEGH VDVVDLLLEG GADVDHTDNN
781: GRTPLLAAAS MGHASVVNTL LFWGAAVDSI DSEGRTVLSI ASAQGNVEVV RTLLDRGLDE
841: NHRDDAGWTP LHMAAFEGHR LICEALIEQG ARTNEIDNDG RIPFILASQE GHYDCVQILL
901: ENKSNIDQRG YDGRNALRVA ALEGHRDIVE LLFSHGADVN CKDADGRPTL YILALENQLT
961: MAEYFLENGA NVEASDAEGR TALHVSCWQG HMEMVQVLIA YHADVNAADN EKRSALQSAA
1021: WQGHVKVVQL LIEHGAVVDH TCNQGATALC IAAQEGHIDV VQVLLEHGAD PNHADQFGRT
1081: AMRVAAKNGH SQIIKLLEKY GASSLNGCSP SPVHTMEQKP LQSLSSKVQS LTIKSNSSGS
1141: TGGGDMQPSL RGLPNGPTHA FSSPSESPDS TVDRQKSSLS NNSLKSSKNS SLRTTSSTAT
1201: AQTVPIDSFH NLSFTEQIQQ HSLPRSRSRQ SIVSPSSTTQ SLGQSHNSPS SEFEWSQVKP
1261: SLKSTKASKG GKSENSAKSG SAGKKAKQSN SSQPKVLEYE MTQFDRRGPI AKSGTAAPPK
1321: QMPAESQCKI MIPSAQQEIG RSQQQFLIHQ QSGEQKKRNG IMTNPNYHLQ SNQVFLGRVS
1381: VPRTMQDRGH QEVLEGYPSS ETELSLKQAL KLQIEGSDPS FNYKKETPL