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9.A.3.1.1
The PDZ domain-containing SNX27-retromer assembly apparatus together with the retromer subunit, ANKRD50 (Kvainickas et al. 2016). Retromer subunits include VPS26A/B (327 and 336 aas, respectively) (also cargo binding proteins) VPS35 (MEM3; 796 aas) and VPS29 (DC7, DC15; 182 aas).  SNX3 (162 aas) and Rab7A (207 aas) mediate recruitment to endosomes, but SNX3 is also a cargo adaptor (McNally and Cullen 2018). Kidins220 deficiency causes ventriculomegaly via SNX27-retromer-dependent AQP4 degradation (Del Puerto et al. 2021).

Accession Number:Q9ULJ7
Protein Name:Ankyrin repeat domain-containing protein 50
Length:1429
Molecular Weight:155859.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Endosome1
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MTNPWEEKVC KMAQTSLLQG KQFYCREWVF HKLQHCLQEK SNCCNSAVNA PSLVMNSGNN 
61:	ASGVSGKGAA WGVLLVGGPG SGKTALCTEL LWPSSPASLQ RGLHRQALAF HFCKAQDSDT 
121:	LCVGGFIRGL VAQICRSGLL QGYEDKLRDP AVQSLLQPGE CERNPAEAFK RCVLLPLLGM 
181:	KPPQQSLYLL VDSVDEGCNI TEGEQTSTSL SGTVAALLAG HHEFFPPWLL LLCSARKQSK 
241:	AVTKMFTGFR KISLDDLRKA YIVKDVQQYI LHRLDQEEAL RQHLTKETAE MLNQLHIKSS 
301:	GCFLYLERVL DGVVENFIML REIRDIPGTL NGLYLWLCQR LFVRKQFAKV QPILNVILAA 
361:	CRPLTITELY HAVWTKNMSL TLEDFQRKLD ILSKLLVDGL GNTKILFHYS FAEWLLDVKH 
421:	CTQKYLCNAA EGHRMLAMSY TCQAKNLTPL EAQEFALHLI NSNLQLETAE LALWMIWNGT 
481:	PVRDSLSTLI PKEQEVLQLL VKAGAHVNSE DDRTSCIVRQ ALEREDSIRT LLDNGASVNQ 
541:	CDSNGRTLLA NAAYSGSLDV VNLLVSRGAD LEIEDAHGHT PLTLAARQGH TKVVNCLIGC 
601:	GANINHTDQD GWTALRSAAW GGHTEVVSAL LYAGVKVDCA DADSRTALRA AAWGGHEDIV 
661:	LNLLQHGAEV NKADNEGRTA LIAAAYMGHR EIVEHLLDHG AEVNHEDVDG RTALSVAALC 
721:	VPASKGHASV VSLLIDRGAE VDHCDKDGMT PLLVAAYEGH VDVVDLLLEG GADVDHTDNN 
781:	GRTPLLAAAS MGHASVVNTL LFWGAAVDSI DSEGRTVLSI ASAQGNVEVV RTLLDRGLDE 
841:	NHRDDAGWTP LHMAAFEGHR LICEALIEQG ARTNEIDNDG RIPFILASQE GHYDCVQILL 
901:	ENKSNIDQRG YDGRNALRVA ALEGHRDIVE LLFSHGADVN CKDADGRPTL YILALENQLT 
961:	MAEYFLENGA NVEASDAEGR TALHVSCWQG HMEMVQVLIA YHADVNAADN EKRSALQSAA 
1021:	WQGHVKVVQL LIEHGAVVDH TCNQGATALC IAAQEGHIDV VQVLLEHGAD PNHADQFGRT 
1081:	AMRVAAKNGH SQIIKLLEKY GASSLNGCSP SPVHTMEQKP LQSLSSKVQS LTIKSNSSGS 
1141:	TGGGDMQPSL RGLPNGPTHA FSSPSESPDS TVDRQKSSLS NNSLKSSKNS SLRTTSSTAT 
1201:	AQTVPIDSFH NLSFTEQIQQ HSLPRSRSRQ SIVSPSSTTQ SLGQSHNSPS SEFEWSQVKP 
1261:	SLKSTKASKG GKSENSAKSG SAGKKAKQSN SSQPKVLEYE MTQFDRRGPI AKSGTAAPPK 
1321:	QMPAESQCKI MIPSAQQEIG RSQQQFLIHQ QSGEQKKRNG IMTNPNYHLQ SNQVFLGRVS 
1381:	VPRTMQDRGH QEVLEGYPSS ETELSLKQAL KLQIEGSDPS FNYKKETPL