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1.A.69.1.1
Heteromeric odorant receptor, OR (Sato et al., 2008). OR22a senses fruit-derived esters. These olfactory receptors may have 3-d structures resembling animal rhodopsins, human citronellic terpenoid receptors, OR1A1 and OA1A2 and the mouse eugenol receptor, OR-EG (Ramdya and Benton, 2010). Molecular modelling of oligomeric states of DmOR83b has been reported (Harini and Sowdhamini, 2012).  Recombinant receptor together with the co-receptor, Orco, has been overproduced, purified and reconstituted in a lipid bilayer (Carraher et al. 2013).  Orco (Or83b) forms a dimer that is fully functional for Ca2+ transport, is regulated by calmodulin and interacts normally with Or22a.  The native Orco is therefore probably a dimer (Mukunda et al. 2014).

Accession Number:Q9VNB5
Protein Name:OR83b
Length:486
Molecular Weight:54413.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate calcium(2+)

Cross database links:

DIP: DIP-29174N
RefSeq: NP_001097687.1    NP_524235.2   
Entrez Gene ID: 40650   
Pfam: PF02949   
BioCyc: DMEL-XXX-02:DMEL-XXX-02-010060-MONOMER   
KEGG: dme:Dmel_CG1060   

Gene Ontology

GO:0030425 C:dendrite
GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005549 F:odorant binding
GO:0004984 F:olfactory receptor activity
GO:0042803 F:protein homodimerization activity
GO:0007186 P:G-protein coupled receptor protein signalin...
GO:0042048 P:olfactory behavior
GO:0019236 P:response to pheromone
GO:0007608 P:sensory perception of smell
GO:0007165 P:signal transduction

References (8)

[1] “Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction.”  Larsson M.C.et.al.   15339651
[2] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[3] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572
[4] “A spatial map of olfactory receptor expression in the Drosophila antenna.”  Vosshall L.B.et.al.   10089887
[5] “Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo.”  Benton R.et.al.   16402857
[6] “Membrane topology of the Drosophila OR83b odorant receptor.”  Lundin C.et.al.   18005664
[7] “Insect olfactory receptors are heteromeric ligand-gated ion channels.”  Sato K.et.al.   18408712
[8] “Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels.”  Wicher D.et.al.   18408711

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MTTSMQPSKY TGLVADLMPN IRAMKYSGLF MHNFTGGSAF MKKVYSSVHL VFLLMQFTFI 
61:	LVNMALNAEE VNELSGNTIT TLFFTHCITK FIYLAVNQKN FYRTLNIWNQ VNTHPLFAES 
121:	DARYHSIALA KMRKLFFLVM LTTVASATAW TTITFFGDSV KMVVDHETNS SIPVEIPRLP 
181:	IKSFYPWNAS HGMFYMISFA FQIYYVLFSM IHSNLCDVMF CSWLIFACEQ LQHLKGIMKP 
241:	LMELSASLDT YRPNSAALFR SLSANSKSEL IHNEEKDPGT DMDMSGIYSS KADWGAQFRA 
301:	PSTLQSFGGN GGGGNGLVNG ANPNGLTKKQ EMMVRSAIKY WVERHKHVVR LVAAIGDTYG 
361:	AALLLHMLTS TIKLTLLAYQ ATKINGVNVY AFTVVGYLGY ALAQVFHFCI FGNRLIEESS 
421:	SVMEAAYSCH WYDGSEEAKT FVQIVCQQCQ KAMSISGAKF FTVSLDLFAS VLGAVVTYFM 
481:	VLVQLK