The multicomponent Retriever-CCC-WASH Complex (formerly called the PDZ domain-containing SNX31-retromer assembly apparatus). The CCC and WASH complexes appear to function in recruitment to the endosomes. Direct cargo binding may be mediated by the COMMDs (McNally and Cullen 2018). The structure of the membrane-assembled retromer coat has been determined by cryo-electron tomography (Kovtun et al. 2018) (see family description). These two complexes and their functions have been reviewed (Chen et al. 2019).
|Protein Name:||WASH complex subunit 3|
|Species:||Homo sapiens (Human)  |
|Location1 / Topology2 / Orientation3:
1: MDEDGLPLMG SGIDLTKVPA IQQKRTVAFL NQFVVHTVQF LNRFSTVCEE KLADLSLRIQ
61: QIETTLNILD AKLSSIPGLD DVTVEVSPLN VTSVTNGAHP EATSEQPQQN STQDSGLQES
121: EVSAENILTV AKDPRYARYL KMVQVGVPVM AIRNKMISEG LDPDLLERPD APVPDGESEK
181: TVEESSDSES SFSD