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9.A.3.1.2
The multicomponent Retriever-CCC-WASH Complex (formerly called the PDZ domain-containing SNX31-retromer assembly apparatus). The CCC and WASH complexes appear to function in recruitment to the endosomes. Direct cargo binding may be mediated by the COMMDs (McNally and Cullen 2018).  The structure of the membrane-assembled retromer coat has been determined by cryo-electron tomography (Kovtun et al. 2018) (see family description). These two complexes and their functions have been reviewed (Chen et al. 2019).

Accession Number:Q9Y4E1
Protein Name:WASH complex subunit 2C
Length:1318
Molecular Weight:144668.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Early endosome membrane1
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MMNRTTPDQE LVPASEPVWE RPWSVEEIRR SSQSWSLAAD AGLLQFLQEF SQQTISRTHE 
61:	IKKQVDGLIR ETKATDCRLH NVFNDFLMLS NTQFIENRVY DEEVEEPVLK AEAEKTEQEK 
121:	TREQKEVDLI PKVQEAVNYG LQVLDSAFEQ LDIKAGNSDS EEDDANGRVE LILEPKDLYI 
181:	DRPLPYLIGS KLFMEQEDVG LGELSSEEGS VGSDRGSIVD TEEEKEEEES DEDFAHHSDN 
241:	EQNQHTTQMS DEEEDDDGCD LFADSEKEEE DIEDIEENTR PKRSRPTSFA DELAARIKGD 
301:	AMGRVDEEPT TLPSGEAKPR KTLKEKKERR TPSDDEEDNL FAPPKLTDED FSPFGSGGGL 
361:	FSGGKGLFDD EDEESDLFTE ASQDRQAGAS VKEESSSSKP GKKIPAGAVS VFLGDTDVFG 
421:	AASVPSLKEP QKPEQPTPRK SPYGPPPTGL FDDDDGDDDD DFFSAPHSKP SKTRKVQSTA 
481:	DIFGDEEGDL FKEKAVASPE ATVSQTDENK ARAEKKVTLS YSKNLKPSSE TKTQKGLFSD 
541:	EEDSEDLFSS QSASNLKGAS LLPGKLPTSV SLFDDEDEED NLFGGTAAKK QTLSLQAQRE 
601:	EKAKASELSK KKASALLFSS DEEWNIPASQ THLASDSRSK GEPRDSGTLQ SQEAKAVKKT 
661:	SLFEEDKEDD LFAIAKDSQK KTQRVSLLFE DDVDSGGSLF GSPPTSVPPA TKKKETVSEA 
721:	PPLLFSDEEE KEAQLGVKSV DKKVESAKES LKFGRTDVAE SEKEGLLTRS AQETVKHSDL 
781:	FSSSSPWDKG TKPRTKTVLS LFDEEEDKME DQNIIQAPQK EVGKGCDPDA HPKSTGVFQD 
841:	EELLFSHKLQ KDNDPDVDLF AGTKKTKLLE PSVGSLFGDD EDDDLFSSAK SQPLVQEKKR 
901:	VVKKDHSVNS FKNQKHPESI QGSKEKGIWK PETPQANLAI NPAALLPTAA SQISEVKPVL 
961:	PELAFPSSEH RRSHGLESVP VLPGSGEAGV SFDLPAQADT LHSANKSRVK MRGKRRPQTR 
1021:	AARRLAAQES SEAEDMSVPR GPIAQWADGA ISPNGHRPQL RAASGEDSTE EALAAAAAPW 
1081:	EGGPVPGVDT SPFAKSLGHS RGEADLFDSG DIFSTGTGSQ SVERTKPKAK IAENPANPPV 
1141:	GGKAKSPMFP ALGEASSDDD LFQSAKPKPA KKTNPFPLLE DEDDLFTDQK VKKNETKSSS 
1201:	QQDVILTTQD IFEDDIFATE AIKPSQKTRE KEKTLESNLF DDNIDIFADL TVKPKEKSKK 
1261:	KVEAKSIFDD DMDDIFSTGI QAKTTKPKSR SAQAAPEPRF EHKVSNIFDD PLNAFGGQ