1.A.1.10.20
Voltage-gated sodium channel of 1836 aas and 24 TMSs, PaFPC1. The 3-d structure has been determined (Shen et al. 2017). It mediates the voltage-dependent sodium ion permeability in excitable membranes.
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| Accession Number: | D0E0C2 |
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| Protein Name: | Sodium channel protein PaFPC1 |
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| Length: | 1553 |
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| Molecular Weight: | 179116.00 |
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| Species: | Periplaneta americana (American cockroach) [6978] |
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| Number of TMSs: | 21 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MADNSPLIRE ERQRLFRPYT RAMLTAPSAQ PAKENGKTEE NKDNSRDKGR GANKDRDGSA
61: HPDQALEQGS RLPARMRNIF PAELASTPLE DFDPFYKNKK TFVVVTKAGD IFRFSGEKSL
121: WMLDPFTPIR RVAISTMVQP IFSYFIMITI LIHCIFMIMP ATQTTYILEL VFLSIYTIEV
181: VVKVLARGFI LHPFAYLRDP WNWLDFLVTL IGYITLVVDL GHLYALRAFR VLRSWRTVTI
241: VPGWRTIVDA LSLSITSLKD LVLLLLFSLF VFAVLGLQIY MGVLTQKCVK HFPADGSWGN
301: FTDERWFNYT SNSSHWYIPD DWIEYPLCGN SSGAGMCPPG YTCLQGYGGN PNYGYTSFDT
361: FGWAFLSVFR LVTLDYWEDL YQLALRSAGP WHILFFIIVV FYGTFCFLNF ILAVVVMSYT
421: HMVKRADEEK AAERELKKEK KAASVANNTA NGQEQTTIEM NGDEAVVIDN NDQAARQQSD
481: PETPAPSVTQ RLTDFLCVWD CCVPWQKLQG AIGAVVLSPF FELFIAVIIV LNITFMALDH
541: HDMNIEFERI LRTGNYIFTS IYIVEAVLKI IALSPKFYFK DSWNVFDFII VVFAILELGL
601: EGVQGLSVFR SFRLLRVFRL AKFWPTLNNF MSVMTKSYGA FVNVMYVMFL LLFIFAIIGM
661: QLFGMNYIDN MERFPDGDLP RWNFTDFLHS FMIVFRALCG EWIESMWDCM LVGDWSCIPF
721: FVAVFFVGNL VILNLLIALL LNNYGSFCTS PTSDEEDSKD EDALAQIVRI FKRFKPNLNA
781: VKLSPMKPDS EDIVESQEIQ GNNIADAEDV LAGEFPPDCC CNAFYKCFPS RPARDSSVQR
841: MWSNIRRVCF LLAKNKYFQK FVTAVLVITS VLLALEDIYL PQRPVLVNIT LYVDYVLTAF
901: FVIEMIIMLF AVGFKKYFTS KWYWLDFIVV VAYLLNFVLM CAGIEALQTL RLLRVFRLFR
961: PLSKVNGMQV VTSTLVEAVP HIFNVILVGI FFWLVFAIMG VQLFAGKFYK CVDENSTVLS
1021: HEITMDRNDC LHENYTWENS PMNFDHVGNA YLSLLQVATF KGWLQIMNDA IDSREVHKQP
1081: IRETNIYMYL YFIFFIVFGS FFILKLFVCI LIDIFRQQRR KAEGLSATDS RTQLIYRRAV
1141: MRTMSAKPVK RIPKPTCHPQ SLMYDISVNR KFEYTMMILI ILNVAVMAID HYGQSMEFSE
1201: VLDYLNLIFI IIFFVECVIK VSGLRHHYFK DPWNIIDFLY VVLAIAGLML SDVIEKYFIS
1261: PTLLRILRIL RVGRLLRYFQ SARGMRLLLL ALRKALRTLF NVSFLLFVIM FVYAVFGMEF
1321: FMHIRDAGAI DDVYNFKTFG QSIILLFQLA TSAGWDGVYF AIANEEDCRA PDHELGYPGN
1381: CGSRALGIAY LVSYLIITCL VVINMYAAVI LDYVLEVYED SKEGLTDDDY DMFFEVWQQF
1441: DPEATQYIRY DQLSELLEAL QPPLQVQKPN KYKILSMNIP ICKDDHIFYK DVLEALVKDV
1501: FSRRGSPVEA GDVQAPNVDE AEYKPVSSTL QRQREEYCVR LIQNAWRKHK QQN