1.A.1.2.28
Potassium voltage-gated channel subfamily D member 1, K_v4.1 of 647 aas and 6 TMSs.  It is the pore-forming α-subunit of a voltage-gated rapidly inactivating A-type potassium channel. It may contribute to I(To) current in the heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other α-subunits and with regulatory subunits, KChIP-1 and DPPX-S. The complex voltage-dependent gating rearrangements are not limited to the membrane-spanning core but include the intracellular T1-T1 tetramerization domains interface (Wang and Covarrubias 2006). Artemisinin has an antiarrhythmic effect on wedge preparation models of Brugada syndrome (BrS). It may work by inhibiting potassium channels including I(to) channels, subsequently suppressing ventricular tachycardia/ventricular fibrillation (Jeong et al. 2023).  The Kv4 potassium channel modulator NS5806 attenuates cardiac hypertrophy (Cai et al. 2024).