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1.A.1.20.2
Erg2 (Kv11.2; KCNH6) K+ channel with slowly activating delayed rectifier (expressed only in the nervous system) (Shi et al., 1997). The human ortholog of 994 aas and 6 TMSs (Q9H252) is 86% identical to the rat protein. KCNH6 in humans and mice plays a key role in insulin secretion and glucose hemostasis (Yang et al. 2018).  GJB2 (TC# 1A.24), KCNH6, and KCNN4 (TC# 1.A.1.16.2) are oncogenic, and GJB2 and KCNN4 were upregulated, while KCNH6 was downregulated in high risk group and glioblastoma (GBM) cells (Huang et al. 2024). The regulatory network showed that KCNH6 was targeted by more miRNAs and transcription factors and KCNN4 interacted with more drugs (Huang et al. 2024).

Accession Number:O54853
Protein Name:Potassium voltage-gated channel subfamily H member 6 aka Kcnh6 aka Erg2
Length:950
Molecular Weight:105706.00
Species:Rattus norvegicus (Rat) [10116]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate potassium(1+)

Cross database links:

RefSeq: NP_446389.1   
Entrez Gene ID: 116745   
Pfam: PF00027    PF00520    PF00989   
KEGG: rno:116745   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005242 F:inward rectifier potassium channel activity
GO:0006813 P:potassium ion transport
GO:0051291 P:protein heterooligomerization
GO:0006355 P:regulation of transcription, DNA-dependent
GO:0007165 P:signal transduction
GO:0055085 P:transmembrane transport

References (4)

[1] “Identification of two nervous system-specific members of the erg potassium channel gene family.”  Shi W.et.al.   9390998
[2] “Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary.”  Wulfsen I.et.al.   10718922
[3] “Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers.”  Wimmers S.et.al.   11212207
[4] “Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain.”  Saganich M.J.et.al.   11425889

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MPVRRGHVAP QNTYLDTIIR KFEGQSRKFL IANAQMENCA IIYCNDGFCE LFGYSRVEVM 
61:	QRPCTCDFLT GPNTPSSAVS RLAQALLGAE ECKVDILYYR KDASSFRCLV DVVPVKNEDG 
121:	AVIMFILNFE DLAQLLAKSS SRSLTQRLLS HSFLGSEGSH SRPSGQGPGP GRGKYRTVSQ 
181:	IPQFTLNFVE FNLEKHRSGS TTEIEIIAPH KVVERTQNVT EKVTQVLSLG ADVLPEYKLQ 
241:	APRIHRGTIL HYSPFKAVWD WLILLLVIYT AVFTPYSAAF LLSDQDESQR GTCGYTCSPL 
301:	TVVDLIVDIM FVVDIVINFR TTYVNTNDEV VSHPRRIAVH YFKGWFLIDM VAAIPFDLLI 
361:	FRTGSDETTT LIGLLKTARL LRLVRVARKL DRYSEYGAAV LFLLMCTFAL IAHWLACIWY 
421:	AIGNVERPYL EPKIGWLDSL GAQLGKQYNG SDPASGPSVQ DKYVTALYFT FSSLTSVGFG 
481:	NVSPNTNSEK VFSICVMLIG SLMYASIFGN VSAIIQRLYS GTARYHTQML RVKEFIRFHQ 
541:	IPNPLRQRLE EYFQHAWSYT NGIDMNAVLK GFPECLQADI CLHLHRALLQ HCPAFRGASK 
601:	GCLRALAVKF KTTHAPPGDT LVHLGDVLST LYFISRGSIE ILRDDVVVAI LGKNDIFGEP 
661:	ASLHARPGKS SADVRALTYC DLHKIHRADL LEVLDMYPAF ADTFWNKLEV TFNLRDADGG 
721:	LQSTPRQAPG HQDPQGFFLN DSQSGAAPSL SISDTSALWP ELLQQMPPSP PNPRQDLDCW 
781:	HRELGFKLEQ LQAQMNRLES RVSSDLSRIL QLLQHPQGRP SYILGASASS DLASFPETSV 
841:	TRSSESTLLV GHVPSAQTLS YGDLDDHIQT PRNFSPRTPH VAMAMDKTLV PSSEQEQPGG 
901:	LLSPLASPLR PLEVPGLGGS RFPSLPEHLS SVPKQLEFQR HGSDPGFTRS