1.A.104.1.1
The FlhA flagellar biosyththesis energizer Na+ channel of 692 aas and 8 TMSs. Evidence for the Na+ channel activity of FlhA has been presented (Minamino et al. 2016). FlhA and FlhB are transmembrane proteins of the flagellar type III protein export apparatus (TC# 3.A.6), and their C-terminal cytoplasmic domains (FlhAC and FlhBC) coordinate flagellar protein export with assembly. Their (Minamino et al. 2020). FliK-driven conformational rearrangements of FlhA and FlhB are required for export switching of the flagellar protein export apparatus (Minamino et al. 2020).
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| Accession Number: | P76298 |
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| Protein Name: | Flagellar biosynthesis protein FlhA |
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| Length: | 692 |
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| Molecular Weight: | 74843.00 |
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| Species: | Escherichia coli (strain K12) [83333] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Cell inner membrane1 / Multi-pass membrane protein2 |
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| Substrate |
sodium(1+) |
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1: MSNLAAMLRL PANLKSTQWQ ILAGPILILL ILSMMVLPLP AFILDLLFTF NIALSIMVLL
61: VAMFTQRTLE FAAFPTILLF TTLLRLALNV ASTRIILMEG HTGAAAAGKV VEAFGHFLVG
121: GNFAIGIVVF VILVIINFMV ITKGAGRIAE VGARFVLDGM PGKQMAIDAD LNAGLIGEDE
181: AKKRRSEVTQ EADFYGSMDG ASKFVRGDAI AGILIMVINI VGGLLVGVLQ HGMSMGHAAE
241: SYTLLTIGDG LVAQIPALVI STAAGVIVTR VSTDQDVGEQ MVNQLFSNPS VMLLSAAVLG
301: LLGLVPGMPN LVFLLFTAGL LGLAWWIRGR EQKAPAEPKP VKMAENNTVV EATWNDVQLE
361: DSLGMEVGYR LIPMVDFQQD GELLGRIRSI RKKFAQEMGF LPPVVHIRDN MDLQPARYRI
421: LMKGVEIGSG DAYPGRWLAI NPGTAAGTLP GEATVDPAFG LNAIWIESAL KEQAQIQGYT
481: VVEASTVVAT HLNHLISQHA AELFGRQEAQ QLLDRVAQEM PKLTEDLVPG VVTLTTLHKV
541: LQNLLDEKVP IRDMRTILET LAEHAPIQSD PHELTAVVRV ALGRAITQQW FPGKDEVHVI
601: GLDTPLERLL LQALQGGGGL EPGLADRLLA QTQEALSRQE MLGAPPVLLV NHALRPLLSR
661: FLRRSLPQLV VLSNLELSDN RHIRMTATIG GK