TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
1.A.106.1.1 | The Transmembrane and coiled-coil domains protein 1 (TMCO1, TMCC4, PNAS-10, PNAS-136, UNQ155) of 188 aas and 3 TMSs. It is an ER transmembrane protein that actively prevents Ca2+ stores from overfilling, acting as a "Cacium Load-activated Calcium channel" or "CLAC" channel. TMCO1 undergoes reversible homotetramerization in response to ER Ca2+ overloading and disassembly upon Ca2+ depletion to form a Ca2+-selective ion channel as demonstrated in liposomes (Wang et al. 2016). TMCO1 knockout mice reproduce the main clinical features of human cerebrofaciothoracic (CFT) dysplasia spectrum, a developmental disorder linked to TMCO1 dysfunction, and exhibit severe mishandling of ER Ca2+ in cells (Alanay et al. 2014). Thus, TMCO1 provides a protective mechanism to prevent overfilling of ER stores with calcium ions (Wang et al. 2016). It regulates Ca2+ stores in granulosa cells (Sun et al. 2018). TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling (Li et al. 2019). The TMCO1 gene is a tumor suppressor in urinary bladder urothelial carcinomas (UBUC). TMCO1 dysregulates cell-cycle progression via suppression of the AKT pathway, and S60 of the TMCO1 protein is crucial for its tumor-suppressor roles (Li et al. 2017). Batchelor-Regan et al. 2021 published a short review about the clinical and scientific advances made with TMCO1. Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling (Yang et al. 2022). A mechanism of metformin action, restoring cellular ER homeostasis, enabled the development of a nanocarrier-mediated ER targeting strategy for remodeling diabetic periodontal tissue (Zhong et al. 2022). TMCO1 regulates cell proliferation, metastasis and EMT signaling through CALR, promoting ovarian cancer progression and cisplatin resistance (Sun et al. 2024). TMCO1 is a crucial regulator of ovarian cancer progression, influencing VDAC1 through CALR and impacting diverse cellular processes (Sun et al. 2024). | Eukaryota |
Metazoa, Chordata | TMCO1, a CLAC channel of Homo sapiens |
1.A.106.1.2 | TMCO1 of 183 aas and 3 TMSs | Eukaryota |
Metazoa, Cnidaria | TMCo1 of Hydra vulgaris (Hydra) (Hydra attenuata) |
1.A.106.1.3 | TMCO1 or Anon-37B-2(TUB2, TuB2, Tu37B2) of 177 aas (Q8IA62) or 183 aas (Q9VJ11) and 3 TMSs. It is a calcium-selective channel required to prevent calcium stores from overfilling. | Eukaryota |
Metazoa, Arthropoda | TMCO1 of Drosophila melanogaster (Fruit fly) |
1.A.106.1.4 | TMCO1 of 177 aas and 3 TMSs | Eukaryota |
Metazoa, Platyhelminthes | TMCO1 of Schistosoma japonicum (Blood fluke) |
1.A.106.1.5 | TMCO1 homologue of 201 aas and 3 TMSs | Eukaryota |
Apicomplexa | TMCO1 homologue of Toxoplasma gondii |
1.A.106.1.6 | Uncharacterized protein of 199 aas and 3 TMSs | Eukaryota |
Viridiplantae, Streptophyta | UP of Zea mays (Maize) |
1.A.106.1.7 | Uncharacterized protein of 219 aas and 3 TMSs | Eukaryota |
Apicomplexa | UP of Eimeria tenella (Coccidian parasite) |
1.A.106.1.8 | Uncharacterized protein of 196 aas and 3 TMSs | Bacteria |
Pseudomonadota | UP of Arabidopsis thaliana |
1.A.106.1.9 | Uncharacterized TMCO1 homologue of 192 aas and 3 TMSs. | Eukaryota |
Viridiplantae, Chlorophyta | UP of Chlamydomonas reinhardtii |
1.A.106.1.10 | Uncharacterized CLAC channel of 176 aas and 3 TMSs. It appears to be a calcium-selective channel required to prevent calcium stores from overfilling. | Eukaryota |
Evosea | CLAC channel of Entamoeba histolytica |
1.A.106.1.11 | Calcium load-activated calcium channel homolog, TMCO1, of 186 aas and 3 TMSs. The low resolution 3-dimensional structure of DdTMCO1 has been determined by solution NMR (Zhang et al. 2020). | Eukaryota |
Evosea | TMCO1 of Dictyostelium discoideum (Slime mold) |
1.A.106.1.12 | Calcium load-activated calcium channel, TMCO1, of 189 aas and 2 or 3 TMSs (Wunderlich 2022). | Eukaryota |
Apicomplexa | TMCO1 of Plasmodium falciparum |
1.A.106.2.1 | TMCO1 homologue of 167 aas and 3 TMSs | Archaea |
Candidatus Korarchaeota | TMCO1 homologue of Korarchaeum cryptofilum |
1.A.106.2.2 | Uncharacterized protein of 174 aas and 3 TMSs | Archaea |
Euryarchaeota | UP of Thermococcus nautili |
1.A.106.2.3 | Uncharacterized protein of 191 aas and 3 TMSs. | Archaea |
Euryarchaeota | UP of Methanobrevibacter smithii |
1.A.106.2.4 | Uncharacterized protein of 301 aas and 4 TMSs | Archaea |
Euryarchaeota | UP of Halorubrum saccharovorum |
1.A.106.2.5 | Uncharactized protein of 193 aas and 3 or 4 TMSs | Archaea |
Euryarchaeota | UP of Ferroglobus placidus |