TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.A.106.1.1









The Transmembrane and coiled-coil domains protein 1 (TMCO1, TMCC4, PNAS-10, PNAS-136, UNQ155) of 188 aas and 3 TMSs. It is an ER transmembrane protein that actively prevents Ca2+ stores from overfilling, acting as a "Cacium Load-activated Calcium channel" or "CLAC" channel. TMCO1 undergoes reversible homotetramerization in response to ER Ca2+ overloading and disassembly upon Ca2+ depletion to form a Ca2+-selective ion channel as demonstrated in liposomes (Wang et al. 2016). TMCO1 knockout mice reproduce the main clinical features of human cerebrofaciothoracic (CFT) dysplasia spectrum, a developmental disorder linked to TMCO1 dysfunction, and exhibit severe mishandling of ER Ca2+ in cells (Alanay et al. 2014). Thus, TMCO1 provides a protective mechanism to prevent overfilling of ER stores with calcium ions (Wang et al. 2016). It regulates Ca2+ stores in granulosa cells (Sun et al. 2018).  TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling (Li et al. 2019). The TMCO1 gene is a tumor suppressor in urinary bladder urothelial carcinomas (UBUC). TMCO1 dysregulates cell-cycle progression via suppression of the AKT pathway, and S60 of the TMCO1 protein is crucial for its tumor-suppressor roles (Li et al. 2017).

Eukaryota
Metazoa
TMCO1, a CLAC channel of Homo sapiens
1.A.106.1.2









TMCO1 of 183 aas and 3 TMSs

Eukaryota
Metazoa
TMCo1 of Hydra vulgaris (Hydra) (Hydra attenuata)
1.A.106.1.3









TMCO1 or Anon-37B-2(TUB2, TuB2, Tu37B2) of 177 aas (Q8IA62) or 183 aas (Q9VJ11) and 3 TMSs. It is a calcium-selective channel required to prevent calcium stores from overfilling.

Eukaryota
Metazoa
TMCO1 of Drosophila melanogaster (Fruit fly)
1.A.106.1.4









TMCO1 of 177 aas and 3 TMSs

Eukaryota
Metazoa
TMCO1 of Schistosoma japonicum (Blood fluke)
1.A.106.1.5









TMCO1 homologue of 201 aas and 3 TMSs

Eukaryota
Apicomplexa
TMCO1 homologue of Toxoplasma gondii
1.A.106.1.6









Uncharacterized protein of 199 aas and 3 TMSs

Eukaryota
Viridiplantae
UP of Zea mays (Maize)
1.A.106.1.7









Uncharacterized protein of 219 aas and 3 TMSs

Eukaryota
Apicomplexa
UP of Eimeria tenella (Coccidian parasite)
1.A.106.1.8









Uncharacterized protein of 196 aas and 3 TMSs

Bacteria
Proteobacteria
UP of Arabidopsis thaliana
1.A.106.1.9









Uncharacterized TMCO1 homologue of 192 aas and 3 TMSs.

Eukaryota
Viridiplantae
UP of Chlamydomonas reinhardtii
1.A.106.1.10









Uncharacterized CLAC channel of 176 aas and 3 TMSs.  It appears to be a calcium-selective channel required to prevent calcium stores from overfilling.

Eukaryota
Entamoebidae
CLAC channel of Entamoeba histolytica
1.A.106.1.11









Calcium load-activated calcium channel homolog, TMCO1, of 186 aas and 3 TMSs. The low resolution 3-dimensional structure of DdTMCO1 has been determined by solution NMR (Zhang et al. 2020).

Eukaryota
Amoebozoa
TMCO1 of Dictyostelium discoideum (Slime mold)
1.A.106.2.1









TMCO1 homologue of 167 aas and 3 TMSs

Archaea
Candidatus Korarchaeota
TMCO1 homologue of Korarchaeum cryptofilum
1.A.106.2.2









Uncharacterized protein of 174 aas and 3 TMSs

Archaea
Euryarchaeota
UP of Thermococcus nautili
1.A.106.2.3









Uncharacterized protein of 191 aas and 3 TMSs.

Archaea
Euryarchaeota
UP of Methanobrevibacter smithii
1.A.106.2.4









Uncharacterized protein of 301 aas and 4 TMSs

Archaea
Euryarchaeota
UP of Halorubrum saccharovorum
1.A.106.2.5









Uncharactized protein of 193 aas and 3 or 4 TMSs

Archaea
Euryarchaeota
UP of Ferroglobus placidus