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1.A.109.1.2
Interleukin 1β, IL1β, IL1beta, IL1B, IL1F2, of 269 aas.  Its release depends on its insertion into the membrane with the formation of a transmembrane pore (Martín-Sánchez et al. 2016). IL-1beta is generated by macrophages upon activation of intracellular NLRP3 (NOD-like, leucine rich repeat domains, and pyrin domain-containing protein 3), part of the functional NLRP3 inflammasome complex that detects pathogenic microorganisms and stressors, while neutrophils are enhanced by increasing levels of IL-1beta (Yaqinuddin and Kashir 2020).

Accession Number:P01584
Protein Name:Interleukin-1 beta
Length:269
Molecular Weight:30748.00
Species:Homo sapiens (Human) [9606]
Location1 / Topology2 / Orientation3: Cytoplasm1
Substrate small molecules, non specific, Interleukin 1beta, protein

Cross database links:

Structure:
1HIB   1I1B   1IOB   1ITB   1L2H   1S0L   1T4Q   1TOO   1TP0   1TWE   [...more]

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL RISDHHYSKG 
61:	FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE EPIFFDTWDN EAYVHDAPVR 
121:	SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ DMEQQVVFSM SFVQGEESND KIPVALGLKE 
181:	KNLYLSCVLK DDKPTLQLES VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST 
241:	SQAENMPVFL GGTKGGQDIT DFTMQFVSS