1.A.110.1.1
OTOP1 of 600 aas and 12 TMSs in a 5 + 5 + 2 arrangement. OTOP1 is a pH-sensitive proton-selective ion channel enriched in
acid-detecting taste receptor cells and is required for their
zinc-sensitive proton conductance (Tu et al. 2018). Two related murine genes, Otop2 and Otop3, and a Drosophila ortholog also encode proton channels. Evolutionary conservation of the
gene family and its widespread tissue distribution suggest a broad role
for proton channels in physiology and pathophysiology (Tu et al. 2018). Structural motifs for subtype-specific pH-sensitive gating of vertebrate otopetrin proton channels have been analyzed (Teng et al. 2022).
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| Accession Number: | Q80VM9 |
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| Protein Name: | Otopetrin-1 |
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| Length: | 600 |
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| Molecular Weight: | 65769.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 10 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
proton |
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1: MPGGPGAPSS PAASSGSSRA APSGIAACPL SPPPLARGSP QASGPRRGAS VPQKLAETLS
61: SQYGLNVFVA GLLFLLAWAV HATGVGKSDL LCVLTALMLL QLLWMLWYVG RSYMQRRLIR
121: PKDTHAGARW LRGSITLFAF ITVVLGCLKV AYFIGFSECL SATEGVFPVT HAVHTLLQVY
181: FLWGHAKDII MSFKTLERFG VIHSVFTNLL LWANSVLNES KHQLNEHKER LITLGFGNIT
241: IVLDDHTPQC NCTPPALCSA LSHGIYYLYP FNIEYQILAS TMLYVLWKNI GRRVDSSQHQ
301: KMQCRFDGVL VGSVLGLTVL AATIAVVVVY MIHIGRSKSK SESALIMFYL YAITVLLLMG
361: AAGLVGSWIY RVDEKSLDES KNPARKLDVD LLVATASGSW LLSWGSILAI ACAETRPPYT
421: WYNLPYSVLV IVEKYVQNIF IIESVHLEPE GVPEDVRTLR VVTVCSSEAA ALAASTLGSQ
481: GMAQDGSPAV NGNLCLQQRC GKEDQESGWE GATGTTRCLD FLQGGMKRRL LRNITAFLFL
541: CNISLWIPPA FGCRPEYDNG LEEIVFGFEP WIIVVNLAMP FSIFYRMHAA AALFEVYCKI