1.A.110.1.5
Zinc-sensitive proton channel, OTOP1, of 586 aas and 10 TMSs in a 5 + 5 + 2 TMS arrangement (Tu et al. 2018). It inhibits P2Y purinoceptors and modulates
calcium homeostasis and influx of calcium in response to extracellular
ATP. It is essential for the formation of otoliths in the
inner ear of developing larvae and for the perception of gravity and
acceleration (Söllner et al. 2004; Hughes et al. 2004). The 3-d structure has been determined by cryoEM (Saotome et al. 2019) (see family description). Mutations in the Otopetrin 1 gene in mice and fish
produce an unusual bilateral vestibular pathology that involves the
absence of otoconia without hearing impairment (Hurle et al. 2011).
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| Accession Number: | Q7ZWK8 |
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| Protein Name: | Otopetrin-1 |
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| Length: | 586 |
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| Molecular Weight: | 65721.00 |
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| Species: | Danio rerio (Zebrafish) [7955] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
calcium ion, proton |
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1: MVEHGGTDSM WLNKYNPAAA SSASSSSSSD AENKLFSRLK VSLTKKYPQK NAELLSAQYG
61: TNLLLLGVSV MLALAAQSGP VKEEHLLSFI TVLMLVQLVW MLCYMIRRER ERSPVPERDA
121: HAGASWIRGG LTMLALLSLI MDAFRIGYFV GYHSCISAAL GVYPIVHALH TISQVHFLWF
181: HIKDVIKKYE TFERFGVIHA VFTNLLLWCN GVMSETEHFM HNHRRRLIEM GYANLSTVDV
241: QPHCNCTTSV CSMFSTSLYY LYPFNIEYHI FVSAMLFVMW KNIGRTLDRH SNRKRRSTGS
301: TGLLLGPLGG LVALASSVSV LVVYLIHLEK TEEMHEAAVS MFYYYGVAMM ACMCVGSGTG
361: LLVYRMENRP MDTGSNPART LDTELLLASS LGSWLMSWCS VVASVAEAGQ KSPSFSWTSL
421: TYSLLLVLEK CIQNLFIVES LYRRHSEEEE DAAAPQVFSV AVPPYDGILN HGYEAHDKHR
481: EAEPAAGSHA LSRKQPDAPL PAGQRLDVTP GRKRQILKNI CMFLFMCNIS LWILPAFGCR
541: PQYDNPLENE TFGTSVWTTV LNVAIPLNLF YRMHSVASLF EVFRKV