1.A.110.1.9
The OTOP3 protopn channel protein of 681 aas and 12 TMSs. The cryo-EM structure along with functional characteristics have been described (Chen et al. 2019). XtOTOP3 forms a homodimer with each subunit containing 12 transmembrane helices that can be divided into two structurally homologous halves; each half assembles as an alpha-helical barrel that could serve as a proton conduction pore.
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| Accession Number: | A9JTM7 |
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| Protein Name: | LOC100127796 protein |
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| Length: | 681 |
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| Molecular Weight: | 76724.00 |
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| Species: | Xenopus tropicalis (Western clawed frog) [8364] |
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| Number of TMSs: | 12 |
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| Substrate |
proton |
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1: MLSKEEPACR QFHSREKTWG NEHNGKTVTQ ANNKEHKVPA VRRGDIGQRE PAAHPASHIQ
61: GTMASENTGE QATCKDQYMD LDAPGNNLEH SWLHRHCEIP TTLHQRAKKT GRLFSGLFGL
121: NLMFLGGTVV SSVALSNKAV PERDSQSFLC ILMLLSSVWA LYHLLFIRNQ NGAVHHDHHA
181: GAMWLKASLA IFGVCSIILS IFEIGHALLL QNCEILMDIV FFSIEIVFVS VQTVLLWVSC
241: KDCVQMHHSV TRYGIMLTLA TDILLWLTAV IDDSLEQDLE ILQSNSTQDE SNEMAQCQCP
301: TDSMCWGLKQ GYVTMFPFNI EYSLICATLL FIMWKNVGRR EKLHSDPPRH TFQLRGIIYG
361: PLIGGAALLV GISVFVQYQV EATSGMVSIL SYHMYYGYKM IILAPMIVCS VAGIIAHSLR
421: EKEKKGQKET GRSDQDWLHM EDVGSENKNT DYSSGQYQSS QGDEKIQGYS LAQFALDNEK
481: EKLEHRQGNT TKKHNTHQGK MKNYTRKLDV TLLFVSAVGQ LGISYFSIIA TVVTTPWTML
541: SALNFSNSLL LILQYLSQTM FIIESMRSIH EEEKEKPGHH EESHRRMSVQ EMHKAPPSCL
601: DAGHLGLSRR VVKEMAMFLM ICNIMCWILG AFGAHPLYMN GLERQLYGSG IWLAILNIGL
661: PLSVFYRMHS VGILLEVYLH A