1.A.112.1.1
Kidney metal (Mg2+) transporter, Cyclin (CNN) M2 isoform CRA_b (CNNM2). Defects cause hypomagnesemia. It has an extracellular N-terminus, an N-terminal TMS, a hydrophilic domain followed by 4 TMSs, another hydrophilic domain, and an intracellular C-terminus (de Baaij et al., 2012). CNNM2a forms heterodimers with the smaller isoform CNNM2b. The human splice variant 1 of CNNM2 (ACDP2; Q9H8M5) is a Mg2+ transporter (Brandao et al. 2012). The Bateman module is involved in AMP binding and Mg2+ sensing, and their binding causes a conformational change in the CBS module, transmitted to the transmembrane domain (Corral-Rodríguez et al. 2014). It may be able to transport divalent metal cations, Mg2+, Co2+, Mn2+, Sr2+, Ba2+, Cu2+, Fe2+ and monvalent cation, Na+. In prokaryotes, homologs are CorB/C.
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| Accession Number: | Q3TWN3 |
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| Protein Name: | Metal transporter CNNM2 |
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| Length: | 875 |
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| Molecular Weight: | 96704.00 |
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| Species: | Mus musculus (Mouse) [10090] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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| Entrez Gene ID: |
94219
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| Pfam: |
PF01595
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| KEGG: |
mmu:94219
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[1] “The transcriptional landscape of the mammalian genome.” Carninci P. et.al. 16141072
[2] “Lineage-specific biology revealed by a finished genome assembly of the mouse.” Church D.M. et.al. 19468303
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Team et.al. 15489334
[4] “Molecular cloning and characterization of the mouse Acdp gene family.” Wang C.-Y. et.al. 14723793
[5] “Functional characterization of ACDP2 (ancient conserved domain protein), a divalent metal transporter.” Goytain A. et.al. 15899945
[6] “Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.” Wollscheid B. et.al. 19349973
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1: MIGCGACEPE VKMAGGQAAA ALPTWKMAAR RSLSARGRGV LQAAAGRLLP LLLLSCCWGA
61: GGCTAAGENE ETVIIGLRLE DTNDVSFMEG GALRVSERTR VKLRVYGQNI NNETWSRIAF
121: TEHERRRHTP SERGLGGPAP PEPDSGPQRC GIRTSDIIIL PHIILNRRTS GIIEIEIKPL
181: RKMEKSKSYY LCTSLSTPAL GAGGSGSASG TVGGKGGAGV AGLPPPPWAE TTWIYHDGED
241: TKMIVGEEKK FLLPFWLQVI FISLLLCLSG MFSGLNLGLM ALDPMELRIV QNCGTEKEKN
301: YAKRIEPVRR QGNYLLCSLL LGNVLVNTTL TILLDDIAGS GLVAVVVSTI GIVIFGEIVP
361: QAICSRHGLA VGANTIFLTK FFMMMTFPAS YPVSKLLDCV LGQEIGTVYN REKLLEMLRV
421: TDPYNDLVKE ELNIIQGALE LRTKTVEDVM TPLRDCFMIT GEAILDFNTM SEIMESGYTR
481: IPVFEGERSN IVDLLFVKDL AFVDPDDCTP LKTITKFYNH PLHFVFNDTK LDAMLEEFKK
541: GKSHLAIVQR VNNEGEGDPF YEVLGIVTLE DVIEEIIKSE ILDETDLYTD NRTKKKVAHR
601: ERKQDFSAFK QTDSEMKVKI SPQLLLAMHR FLATEVEAFS PSQMSEKILL RLLKHPNVIQ
661: ELKYDEKNKK APECYLYQRN KPVDYFVLIL QGKVEVEAGK EGMKFEASAF SYYGVMALTA
721: SPVPLSLSRT FVVSRTEVLA AGSPGENKSP PRPCGLNHSD SLSRSDRIDA MTPTLGSSNN
781: QLSSSFLQVY IPDYSVRALS DLQFVKISRQ QYQNALMASR MDKTPQSSDS ENTKIELTLT
841: ELHDGLPDET ANLLNEQNCV SHNKANHSLH SEGAI