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1.A.112.1.2
Metal transporter CNNM3 (Ancient conserved domain-containing protein 3) (mACDP3) (Cyclin-M3) of 713 aas and probably 5 TMSs with one N-terminal, and four together in the first half of the protein (Chen et al. 2018). See the family description for the domain order of the CNNM proteins.

Accession Number:Q32NY4
Protein Name:Metal transporter CNNM3
Length:713
Molecular Weight:76279.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:3
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Genevestigator: Q32NY4
eggNOG: COG1253
HEGENOM: HOG000231947
Entrez Gene ID: 94218   
Pfam: PF01595   
KEGG: mmu:94218   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006811 P:ion transport

References (6)

[1] “Lineage-specific biology revealed by a finished genome assembly of the mouse.”  Church D.M.et.al.   19468303
[2] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[3] “Molecular cloning and characterization of the mouse Acdp gene family.”  Wang C.-Y.et.al.   14723793
[4] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[5] “The phagosomal proteome in interferon-gamma-activated macrophages.”  Trost M.et.al.   19144319
[6] “Membrane topology and intracellular processing of Cyclin M2 (CNNM2).”  de Baaij J.H.et.al.   22399287
Structure:
5K24     

External Searches:

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  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAAAAAAVVG WLGWVLAAFC LGSTAGEAAP APGAGLLNFC TEEDSAPGAG SLRGRAAPEA 
61:	TLCLRLFCSG LANSSWTWVA AEGAGCPEGG RATEPEEAAA PTGEWRALLR LRAEAGHPRS 
121:	ALLAVRVEPG GGAAEEAAPP WALGLGAAGL LALAAVARGL QLSALALAPA EVQVLRESGS 
181:	EAERAAARRL EPARRWAGCA LGALLLLASL AQAALAVLLY GAAGQRAVPA VLGCAGLVFL 
241:	VGEVLPAAVS GRWALALAPR ALGLSRLAVL LTLPVALPVG QLLELAARPG RLRERVLELA 
301:	RGGGDPYSDL SKGVLRSRTV EDVLTPLEDC FMLDSGTVLD FSVLASIMQS GHTRIPVYEE 
361:	ERSNIVDMLY LKDLAIVEPE DCTPLSTITR FYNHPLHFVF NDTKLDAVLE EFKRGKSHLA 
421:	IVQKVNNEGE GDPFYEVLGL VTLEDVIEEI IKSEILDESE DYSDTKVRKK TVALGAPLKR 
481:	KEEFSLFKVS DDEYKVKISP QLLLATQRFL SREVDVFSPL RVSEKVLLHL LKHPSVNQEV 
541:	TFDESNRLAA HHYLYQRSQP VDYFILILQG RVEVEIGKEG LKFENGAFTY YGVSALTAPS 
601:	SAHQSPVSSR QLIRHDVQPE PADGTRSCTY CPDYTVRALS DLQLIKVTRL QYLNALLATR 
661:	AQSLPPSPEN AELQAIPGSQ TRLLGDKSRE TAGSTNSRPS IPVEESPGRN PGV