1.A.112.1.6
Putative Mg2+ exporter of 875 aas and 5 TMSs, CNNM2 or ACDP2 (Chen et al. 2018). The bacterial CorC is involved in resistance to antibiotic exposure and to the survival of pathogenic microorganisms in their host environments. CorC possesses a cytoplasmic region containing the (regulatory ?) ATP-binding site (Huang et al. 2021). An inhibitor, IGN95a, targets the ATP-binding site and blocks both ATP binding and Mg2+ export. The cytoplasmic domain structure in complex with IGN95a was determined (Huang et al. 2021). With ATP bound to the cytoplasmic domain, the conformational equilibrium of CorC shifts toward the inward-facing state of the transmembrane domain (Huang et al. 2021). These considerations suggest that CorC may be an ATP-driven Mg2+ efflux porter, and if so, the family belongs in TC sub-class, 3.A. CorC homologs may be able to export Mg2+, Co2+, Mn2+, Sr2+, Ba2+, Cu2+ and Fe2+.
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| Accession Number: | Q9H8M5 |
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| Protein Name: | Metal transporter CNNM2 |
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| Length: | 875 |
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| Molecular Weight: | 96623.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 5 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
barium(2+), strontium(2+), magnesium(2+), cobalt(2+), copper(2+), iron(2+), manganese(2+) |
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1: MIGCGACEPK VKMAGGQAAA ALPTWKMAAR RSLSARGRGI LQAAAGRLLP LLLLSCCCGA
61: GGCAAVGENE ETVIIGLRLE DTNDVSFMEG GALRVSERTR VKLRVYGQNI NNETWSRIAF
121: TEHERRRHSP GERGLGGPAP PEPDSGPQRC GIRTSDIIIL PHIILNRRTS GIIEIEIKPL
181: RKMEKSKSYY LCTSLSTPAL GAGGSGSTGG AVGGKGGSGV AGLPPPPWAE TTWIYHDGED
241: TKMIVGEEKK FLLPFWLQVI FISLLLCLSG MFSGLNLGLM ALDPMELRIV QNCGTEKEKN
301: YAKRIEPVRR QGNYLLCSLL LGNVLVNTTL TILLDDIAGS GLVAVVVSTI GIVIFGEIVP
361: QAICSRHGLA VGANTIFLTK FFMMMTFPAS YPVSKLLDCV LGQEIGTVYN REKLLEMLRV
421: TDPYNDLVKE ELNIIQGALE LRTKTVEDVM TPLRDCFMIT GEAILDFNTM SEIMESGYTR
481: IPVFEGERSN IVDLLFVKDL AFVDPDDCTP LKTITKFYNH PLHFVFNDTK LDAMLEEFKK
541: GKSHLAIVQR VNNEGEGDPF YEVLGIVTLE DVIEEIIKSE ILDETDLYTD NRTKKKVAHR
601: ERKQDFSAFK QTDSEMKVKI SPQLLLAMHR FLATEVEAFS PSQMSEKILL RLLKHPNVIQ
661: ELKYDEKNKK APEYYLYQRN KPVDYFVLIL QGKVEVEAGK EGMKFEASAF SYYGVMALTA
721: SPVPLSLSRT FVVSRTELLA AGSPGENKSP PRPCGLNHSD SLSRSDRIDA VTPTLGSSNN
781: QLNSSLLQVY IPDYSVRALS DLQFVKISRQ QYQNALMASR MDKTPQSSDS ENTKIELTLT
841: ELHDGLPDET ANLLNEQNCV THSKANHSLH NEGAI