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1.A.112.2.12
YtfA, DUF21 domain-containing protein, HlyC/CorC family transporter, magnesium and cobalt efflux protein CorC_2 or CorC_3, of 445 aas and 4 N-terminal TMSs plus a large hydrophilic domain as the C-terminal 250 residues. Based on the E. coli ortholog, it probably transports putrescine and canavanine (Iwadate et al. 2021). Klebsiella pneumoniae is a source of widespread contamination of medical equipment, causing pneumonia as well as other multiorgan metastatic infections. During K. pneumoniae infections of lung epithelia, microtubules are severed and then eliminated, and YtfA plays a role, probably by secreting a relevant compound (Chua et al. 2019).

Accession Number:W9BK01
Protein Name:DUF21 domain-containing protein
Length:445
Molecular Weight:49494.00
Species:Klebsiella pneumoniae [573]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MLNSILVILC LIAVSAFFSI SEISLAASRK IKLKLLADEG NVNAQRVLKM QENPGTFFTV 
61:	VQIGLNAVAI LGGIVGDAAF SPAFHSLLSG YLSPELSEQL SFIISFTLVT SLFILFADLT 
121:	PKRIGMIAPE TVALRIINPM RFCLLVFRPL VWLFNGMANM IFRIFKLPMV RKDDITSDDI 
181:	YAVVEAGALA GVLRKQEHEL IENVFELESR TVPSSMTPRE SVIWFDLHED EQSLKNKVAE 
241:	HPHSKFLVCN EDIDHIIGYV DSKDLLNRVL ANQSLVLTGG VQIRNTLIVP DTLTLSEALE 
301:	SFKTAGEDFA VIMNEYALVV GIITLNDVMT TLMGDLVGQG LEEQIVARDE NSWLIDGGTP 
361:	IDDVMRVLDI DEFPQSGNYE TIGGFMMFML RKIPKRTDAV KFSGYKFEVV DIDNYRIDQL 
421:	LVTRIDNKPT VLVPKQAETA ESQNA