1.A.114.1.1
Plasma membrane proton-activated chloride channel, PACC1, or acid-sensitive outwardly-rectifying anion channel PAORAC/ASOR or TMEM206, of 350 aas and 2 TMSs.  Ion permeation-changing mutations along the length of TMS2 and at the end of TMS1 suggest that these segments line the pore. TMEM206 probably has orthologs in all vertebrates (Ullrich et al. 2019).  Knockout of mouse Pac abolished I _Cl,H in neurons and attenuated brain damage after ischemic stroke (Yang et al. 2019). The cryoEM structure (3.1 Å resolution) in active and desensitized states has been determined (Wang et al. 2022). The acid-sensitive site critical for chloral hydrate activation of the proton-activated chloride channel has been identified (Xu et al. 2022). The molecular mechanism underlying desensitization of the proton-activated chloride channel, PAC, has been examined (Osei-Owusu et al. 2022).