| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
1.A.117.1.1 | Matrix (M)-protein (putative viroporin) of 217 aas with 3 closely spaced TMSs in the N-terminal half of the protein. | Viruses |
Nidovirales | M-protein of Guangdong chinese water skink coronavirus |
|
1.A.117.1.2 | Membrane glycoprotein of 222 aas and 3 or 4 TMSs. It is a component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins. However, it may also function a viroporin, Orf3a (Barrantes 2021). Variants of the M protein arise with high frequency, suggesting that these mutants are more biologically fit, perhaps related to glucose uptake during viral replication (Shen et al. 2021). Zhang et al. 2022 reported the cryo-EM structure of the SARS-CoV-2 M protein in two different conformations. M protein forms a mushroom-shaped dimer, composed of two transmembrane domain-swapped three-helix bundles and two intravirion domains. It also assembles into higher-order oligomers. A highly conserved hinge region is key for conformational changes. The M protein dimer is similar to SARS-CoV-2 ORF3a, a viroporin (TC# 1.A.57.1.5). Interaction analyses of M protein with nucleocapsid protein (N) and RNA suggest that the M protein mediates the concerted recruitment of these components through the positively charged intravirion domain (Zhang et al. 2022).
| Viruses |
Nidovirales | M-protein of severe acute respiratory syndrome coronavirus 2, SARS CoV2. |
|
1.A.117.1.3 | M-protein of 268 aas and 3 N-terminal TMSs | Viruses |
Nidovirales | M protein of Common moorhen coronavirus HKU21 |
|
1.A.117.1.4 | Membrane matrix (M) glycoprotein of 261 aas and 3 strongly hydrophobic TMSs in the N-terminal half of the protein, preceded by a single N-terminal TMS (possibly a targetting signal sequence), followed by a relatively hydrophilic C-terminal half that includes 3 weakly hydrophobic peaks that could be transmembrane but probably are not. These properties are characteristic of many but not all of the members of this family, including members of both sub-families, 1.A.57.1 and 1.A. 57.2. | Viruses |
Nidovirales | M-protein of the transmissible gastroenteritis virus (TGEV) |
|
1.A.117.1.5 | Matrix (M) protein of 219 aas and 3 N-terminal TMSs. | Viruses |
Nidovirales | M protein (MERS) of betacoronavirus England 1 |
|
1.A.117.1.6 | Membrane (M)-protein of 275 aas and 3 (+ 2 or 3 possible) TMSs | Viruses |
Riboviria | M-protein of Bottlenose dolphin coronavirus |
|
1.A.117.1.7 | M-protein, or "M" of 225 aas and 3 TMSs. It is a component of the viral envelope that plays a central role in virus morphogenesis and assembly via its interactions with other viral proteins. | Eukaryota |
Viridiplantae | M of Avian infectious bronchitis virus (strain DE072) (IBV) |