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1.A.118.1.1
Cyclotide, kalata-B1, kB1. Targets membranes in a process that depends on lipid interactions; hemolytic; can disrupt HIV membranes (Henriques et al., 2011).

Accession Number:P56254
Protein Name:Kalata-B1
Length:124
Molecular Weight:13271.00
Species:Oldenlandia affinis [60225]
Number of TMSs:1
Substrate

Cross database links:

Pfam: PF03784   

Gene Ontology

GO:0019835 P:cytolysis
GO:0042742 P:defense response to bacterium
GO:0044179 P:hemolysis in other organism

References (8)

[1] “Biosynthesis and insecticidal properties of plant cyclotides: the cyclic knotted proteins from Oldenlandia affinis.”  Jennings C.V.et.al.   11535828
[2] “Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1.”  Saether O.et.al.   7703226
[3] “The cyclotide fingerprint in Oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.”  Plan M.R.R.et.al.   17534989
[4] “An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.”  Tam J.P.et.al.   10430870
[5] “Refined structure and metal binding site of the kalata B1 peptide.”  Skjeldal L.et.al.   11888199
[6] “Disulfide folding pathways of cystine knot proteins. Tying the knot within the circular backbone of the cyclotides.”  Daly N.L.et.al.   12482862
[7] “Twists, knots, and rings in proteins. Structural definition of the cyclotide framework.”  Rosengren K.J.et.al.   12482868
[8] “Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity.”  Barry D.G.et.al.   12779323
Structure:
1JJZ   1K48   1KAL   1N1U   1NB1   1ORX   1ZNU   2F2I   2F2J   2JUE   [...more]

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAKFTVCLLL CLLLAAFVGA FGSELSDSHK TTLVNEIAEK MLQRKILDGV EATLVTDVAE 
61:	KMFLRKMKAE AKTSETADQV FLKQLQLKGL PVCGETCVGG TCNTPGCTCS WPVCTRNGLP 
121:	SLAA