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1.A.118.1.1 Cyclotide, kalata-B1, kB1. Targets membranes in a process that depends on lipid interactions; hemolytic; can disrupt HIV membranes (Henriques et al., 2011).
Accession Number:	P56254
Protein Name:	Kalata-B1
Length:	124
Molecular Weight:	13271.00
Species:	Oldenlandia affinis [60225]
Number of TMSs:	1
Substrate

Structure:
Pfam:	PF03784
Gene Ontology GO:0019835 P:cytolysis GO:0042742 P:defense response to bacterium GO:0044179 P:hemolysis in other organism
References (8) [1] “Biosynthesis and insecticidal properties of plant cyclotides: the cyclic knotted proteins from Oldenlandia affinis.” Jennings C.V.et.al. 11535828 [2] “Elucidation of the primary and three-dimensional structure of the uterotonic polypeptide kalata B1.” Saether O.et.al. 7703226 [3] “The cyclotide fingerprint in Oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides.” Plan M.R.R.et.al. 17534989 [4] “An unusual structural motif of antimicrobial peptides containing end-to-end macrocycle and cystine-knot disulfides.” Tam J.P.et.al. 10430870 [5] “Refined structure and metal binding site of the kalata B1 peptide.” Skjeldal L.et.al. 11888199 [6] “Disulfide folding pathways of cystine knot proteins. Tying the knot within the circular backbone of the cyclotides.” Daly N.L.et.al. 12482862 [7] “Twists, knots, and rings in proteins. Structural definition of the cyclotide framework.” Rosengren K.J.et.al. 12482868 [8] “Linearization of a naturally occurring circular protein maintains structure but eliminates hemolytic activity.” Barry D.G.et.al. 12779323
1JJZ 1K48 1KAL 1N1U 1NB1 1ORX 1ZNU 2F2I 2F2J 2JUE [...more]

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

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FASTA formatted sequence

1:	MAKFTVCLLL CLLLAAFVGA FGSELSDSHK TTLVNEIAEK MLQRKILDGV EATLVTDVAE 
61:	KMFLRKMKAE AKTSETADQV FLKQLQLKGL PVCGETCVGG TCNTPGCTCS WPVCTRNGLP 
121:	SLAA

1.A.118.1.1
Cyclotide, kalata-B1, kB1. Targets membranes in a process that depends on lipid interactions; hemolytic; can disrupt HIV membranes (Henriques et al., 2011).

Cross database links:

Gene Ontology

References (8)

External Searches:

Analyze:

1.A.118.1.1Cyclotide, kalata-B1, kB1. Targets membranes in a process that depends on lipid interactions; hemolytic; can disrupt HIV membranes (Henriques et al., 2011).

Cross database links:

Gene Ontology

References (8)

External Searches:

Analyze:

1.A.118.1.1
Cyclotide, kalata-B1, kB1. Targets membranes in a process that depends on lipid interactions; hemolytic; can disrupt HIV membranes (Henriques et al., 2011).