TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.A.119.1.1









The drought stress-inducible putative membrane protein, TMPIT1

Eukaryota
Viridiplantae
TMPIT1 of Triticum dicoccoides (G0ZL54)
1.A.119.1.2









The TMEM120A or TACAN protein, of 343 aas and 7 TMSs.  May function in adipogenesis (Batrakou et al. 2015). TACAN is reported to be a Ca2+-transporting ion channel involved in sensing mechanical pain. It is expressed in a subset of nociceptors in humans, and its heterologous expression increases mechanically evoked currents in cell lines. Purification and reconstitution of TACAN in synthetic lipids generates a functional ion channel that transports Ca2+ (Beaulieu-Laroche et al. 2020). However, Niu et al. 2021 failed to detect the proposed mechanosensitive ion channel activity of TACAN. Using membrane reconstitution methods, they found that TACAN, at high protein concentrations, produces heterogeneous conduction levels that are not mechanosensitive and are most consistent with disruptions of the lipid bilayer. They determined the structure of TACAN using single-particle cryo-EM and observed that it is a symmetrical dimeric transmembrane protein. Each protomer contains an intracellular-facing cleft with a coenzyme A cofactor, confirmed by mass spectrometry. The TACAN protomer is related in three-dimensional structure to a fatty acid elongase, ELOVL7. Thus, TACAN may not be a mechanosensitive ion channel. It may not mediate poking- or stretch-induced channel activities (Rong et al. 2021; Xue et al. 2021).

Eukaryota
Metazoa
TACAN of Homo sapiens
1.A.119.1.3









TACAN-like protein (homologue) of 199 aas and 7 TMSs

Eukaryota
Metazoa
TACAN of Arabidopsis thaliana (thale cress)
1.A.119.1.4









Uncharacterized protein of 113 aas and 2 TMSs. This protein corresponds to the last two TMSs in 1.A.119.1.2.  It could be a short version of the latter protein, or it could be an incomplete sequence.

Eukaryota
Metazoa
UP of Schistosoma curassoni
1.A.119.1.5









Uncharacterized protein of 105 aas and 2 TMSs. This protein corresponds to the last two TMSs of the protein listed under TC# 1.A.119.1.2.  It could be a short version of the latter protein, or it could be an incomplete sequence.

Eukaryota
Metazoa
UP of Dibothriocephalus latus
1.A.119.1.6









Uncharacterized protein of 131 aas and 2 TMSs. This protein corresponds to the last two TMSs of the protein with TC# 1.A.119.1.2.  It could be a short version of the latter protein, or it could be an incomplete sequence. However, there seem to be multiple versions of this short protein (see TC#s 1.A.119.1.4, 1.5, and 1.6) suggesting that it may be a full-length protein. Also, the two N-terminal TMSs are followed in this protein by a hydrophilic region not present in the other homologues.

Eukaryota
Metazoa
UP of Nippostrongylus brasiliensis
1.A.119.1.7









Uncharacterized protein of 268 aas with two C-terminal TMSs and a long hydrophilic N-terminal domain. The C-terminus is very similar to that of TC# 1.A.119 .1.5.

Eukaryota
Metazoa
UP of Schistocephalus solidus
1.A.119.1.8









TMPIT-like protein of 355 aas and 7 TMSs

Eukaryota
Viridiplantae
TMPIT protein of Dunaliella salina
1.A.119.1.9









Transmembrane 120-like protein of 747 aas and 8 probable TMSs in the central part of the protein.

Eukaryota
Viridiplantae
TMEM120 of Chlorella sorokiniana
1.A.119.1.10









Uncharacterized protein of 124 aas and 2 TMSs. This could be a fragment.

Archaea
UP of an archaeon (phyllosphere metagenome)
1.A.119.1.11









Uncharacterized protein of 409 aas and 7 TMSs.

Eukaryota
Viridiplantae
UP of Chlorella variabilis
1.A.119.1.12









Uncharacterized protein of 325 aas and 5 TMSs in a 2 + 1 + 2 TMS arrangement.

Eukaryota
Rhizaria
UP of Reticulomyxa filosa