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1.A.12.1.1
Organellar chloride (anion selective) channel, p64 (outwardly rectifying) (437 aas and 1 TMS). CLIC5 was the first mitochondrial chloride channel to be identified in the inner mitochondrial membrane, while CLIC4 is located predominantly in the outer mitochondrial membrane. Gururaja Rao et al. 2020 discussed the intracellular chloride channels, their roles in pathologies, such as cardiovascular, cancer, and neurodegenerative diseases, and developments concerning their usage as theraputic targets in humans.

Accession Number:P35526
Protein Name:CLIC5
Length:437
Molecular Weight:48959.00
Species:Bos taurus (Bovine) [9913]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Golgi apparatus1 / Single-pass membrane protein2
Substrate Cl-

Cross database links:

eggNOG: maNOG08383
RefSeq: NP_776701.1   
Entrez Gene ID: 281696   
KEGG: bta:281696   

Gene Ontology

GO:0034707 C:chloride channel complex
GO:0016023 C:cytoplasmic membrane-bounded vesicle
GO:0005794 C:Golgi apparatus
GO:0005792 C:microsome
GO:0005815 C:microtubule organizing center
GO:0005886 C:plasma membrane
GO:0005247 F:voltage-gated chloride channel activity
GO:0006821 P:chloride transport

References (2)

[1] “Molecular cloning and characterization of p64, a chloride channel protein from kidney microsomes.”  Landry D.W.et.al.   7686908
[2] “A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons.”  Chuang J.Z.et.al.   10191309

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MNDENYSTTI YNRVQTERVY EDSDPAENGG PLYDEVHEDV RREDNLYVNE LENQEYDSVA 
61:	VYPVGRQGRT SASLQPETGE YVLPDEPYSK AQDPHPGEPT ADEDISLEEL LSPTKDHQSD 
121:	SEEPQASDPE EPQASDPEEP QGPDPEEPQE NGNEMEADLP SPSSFTIQNS RAFSTREISP 
181:	TSYSADDVSE GNESASASPE INLFVKAGID GESIGNCPFS QRLFMILWLK GVVFNVTTVD 
241:	LKRKPADLHN LAPGTHPPFL TFNGDVKTDV NKIEEFLEET LTPEKYPRLA AKHRESNTAG 
301:	IDIFVKFSAY IKNTKQQSNA ALERGLTKAL KKLDDYLNTP LPEEIDADTR GDDEKGSRRK 
361:	FLDGDELTLA DCNLLPKLHV VKIVAKKYRN YDFPAEMTGL WRYLKNAYAR DEFTNTCAAD 
421:	SEIELAYADV AKRLSRS