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1.A.12.1.4
Organellar chloride channel CLIC-6 (CLIC6; 704 aas with two peaks of hydrophobicity between residues 440 and 515). The C-terminal half (residues 400-704) resembles a CLIC channel; the N-terminal half (residues 104-356) resembles a repeated C-terminal region of the bovine Na+/Ca2+,K+ exchanger (TC #2.A.19.4.1) as well as several other bacterial and eukaryotic proteins.  This protein inserts into membrane and displays ion conductances with Cl- > Br- > F- > K+.  IAA-94 is a CLIC-specific blocker.  Channel activity is regulated by pH and redox potential (Loyo-Celis et al. 2023).

Accession Number:Q96NY7
Protein Name:Chloride intracellular channel 6 aka CLIC6
Length:704
Molecular Weight:73012.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:1
Location1 / Topology2 / Orientation3: Cytoplasm1 / Single-pass membrane protein2
Substrate chloride

Cross database links:

RefSeq: NP_444507.1   
Entrez Gene ID: 54102   
KEGG: hsa:54102   

Gene Ontology

GO:0034707 C:chloride channel complex
GO:0005737 C:cytoplasm
GO:0005886 C:plasma membrane
GO:0005247 F:voltage-gated chloride channel activity
GO:0006821 P:chloride transport

References (5)

[1] “Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12.”  Friedli M.et.al.   14597386
[2] “Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q.”  Strippoli P.et.al.   12226712
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The DNA sequence of human chromosome 21.”  Hattori M.et.al.   10830953
[5] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MAEAAEPEGV APGPQGPPEV PAPLAERPGE PGAAGGEAEG PEGSEGAEEA PRGAAAVKEA 
61:	GGGGPDRGPE AEARGTRGAH GETEAEEGAP EGAEVPQGGE ETSGAQQVEG ASPGRGAQGE 
121:	PRGEAQREPE DSAAPERQEE AEQRPEVPEG SASGEAGDSV DAEGPLGDNI EAEGPAGDSV 
181:	EAEGRVGDSV DAEGPAGDSV DAEGPLGDNI QAEGPAGDSV DAEGRVGDSV DAEGPAGDSV 
241:	DAEGRVGDSV EAGDPAGDGV EAGVPAGDSV EAEGPAGDSM DAEGPAGRAR RVSGEPQQSG 
301:	DGSLSPQAEA IEVAAGESAG RSPGELAWDA AEEAEVPGVK GSEEAAPGDA RADAGEDRVG 
361:	DGPQQEPGED EERRERSPEG PREEEAAGGE EESPDSSPHG EASRGAAEPE AQLSNHLAEE 
421:	GPAEGSGEAA RVNGRREDGE ASEPRALGQE HDITLFVKVK LTALGCSRIA IKKYLRAGYD 
481:	GESIGNCPFS QRLFMILWLK GVIFNVTTVD LKRKPADLQN LAPGTNPPFM TFDGEVKTDV 
541:	NKIEEFLEEK LAPPRYPKLG TQHPESNSAG NDVFAKFSAF IKNTKKDANE IHEKNLLKAL 
601:	RKLDNYLNSP LPDEIDAYST EDVTVSGRKF LDGDELTLAD CNLLPKLHII KIVAKKYRDF 
661:	EFPSEMTGIW RYLNNAYARD EFTNTCPADQ EIEHAYSDVA KRMK