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1.A.12.1.5 The Janus protein, CLIC2. The 3-D structure of its water soluble form has been determined at 1.8 Å resolution (Cromer et al., 2007). CLIC2 interacts with the skeletal ryanodine receptor (RyR1) and modulates its channel activity (Meng et al., 2009).
Accession Number:	O15247
Protein Name:	CLIC2
Length:	247
Molecular Weight:	28356.00
Species:	Homo sapiens (Human) [9606]
Location¹ / Topology² / Orientation³:	Cytoplasm¹ / Single-pass membrane protein²
Substrate	chloride

Structure:
RefSeq:	NP_001280.3
Entrez Gene ID:	1193
Pfam:	PF00462
OMIM:	300138 gene
KEGG:	hsa:1193
Gene Ontology GO:0034707 C:chloride channel complex GO:0005737 C:cytoplasm GO:0005634 C:nucleus GO:0009055 F:electron carrier activity GO:0015035 F:protein disulfide oxidoreductase activity GO:0005247 F:voltage-gated chloride channel activity GO:0045454 P:cell redox homeostasis GO:0006821 P:chloride transport GO:0007165 P:signal transduction
References (9) [1] “Genomic structure of a novel chloride channel gene, CLIC2, in Xq28.” Heiss N.S.et.al. 9339381 [2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.” Ota T.et.al. 14702039 [3] “The DNA sequence of the human X chromosome.” Ross M.T.et.al. 15772651 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Interaction of sedlin with chloride intracellular channel proteins.” Fan L.et.al. 12681486 [6] “CLIC-2 modulates cardiac ryanodine receptor Ca2+ release channels.” Board P.G.et.al. 15147738 [7] “A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP.” Dulhunty A.F.et.al. 15916532 [8] “Structure of the Janus protein human CLIC2.” Cromer B.A.et.al. 17945253 [9] “The crystal structure of human chloride intracellular channel protein 2: a disulfide bond with functional implications.” Mi W.et.al. 18186468
2PER 2R4V 2R5G

UniProt (Universal Protein Resource)
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FASTA formatted sequence

1:	MSGLRPGTQV DPEIELFVKA GSDGESIGNC PFCQRLFMIL WLKGVKFNVT TVDMTRKPEE 
61:	LKDLAPGTNP PFLVYNKELK TDFIKIEEFL EQTLAPPRYP HLSPKYKESF DVGCNLFAKF 
121:	SAYIKNTQKE ANKNFEKSLL KEFKRLDDYL NTPLLDEIDP DSAEEPPVSR RLFLDGDQLT 
181:	LADCSLLPKL NIIKVAAKKY RDFDIPAEFS GVWRYLHNAY AREEFTHTCP EDKEIENTYA 
241:	NVAKQKS

1.A.12.1.5
The Janus protein, CLIC2. The 3-D structure of its water soluble form has been determined at 1.8 Å resolution (Cromer et al., 2007). CLIC2 interacts with the skeletal ryanodine receptor (RyR1) and modulates its channel activity (Meng et al., 2009).

Cross database links:

Gene Ontology

References (9)

External Searches:

Analyze:

1.A.12.1.5The Janus protein, CLIC2. The 3-D structure of its water soluble form has been determined at 1.8 Å resolution (Cromer et al., 2007). CLIC2 interacts with the skeletal ryanodine receptor (RyR1) and modulates its channel activity (Meng et al., 2009).

Cross database links:

Gene Ontology

References (9)

External Searches:

Analyze:

1.A.12.1.5
The Janus protein, CLIC2. The 3-D structure of its water soluble form has been determined at 1.8 Å resolution (Cromer et al., 2007). CLIC2 interacts with the skeletal ryanodine receptor (RyR1) and modulates its channel activity (Meng et al., 2009).