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Accession Number: | Q9Y696 |
Protein Name: | CLIC4 |
Length: | 253 |
Molecular Weight: | 28772.00 |
Species: | Homo sapiens (Human) [9606] |
Number of TMSs: | 1 |
Location1 / Topology2 / Orientation3: | Cytoplasm1 / Single-pass membrane protein2 |
Substrate | chloride |
Cross database links:
RefSeq: | NP_039234.1 |
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Entrez Gene ID: | 25932 |
OMIM: |
606536 gene |
KEGG: | hsa:25932 |
Gene Ontology
GO:0015629
C:actin cytoskeleton
GO:0034707
C:chloride channel complex
GO:0030659
C:cytoplasmic vesicle membrane
GO:0005902
C:microvillus
GO:0005634
C:nucleus
GO:0005886
C:plasma membrane
GO:0005625
C:soluble fraction
GO:0005247
F:voltage-gated chloride channel activity
GO:0030154
P:cell differentiation
GO:0006821
P:chloride transport
GO:0030336
P:negative regulation of cell migration
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References (11)[1] “A novel p64-related Cl- channel: subcellular distribution and nephron segment-specific expression.” Edwards J.C.et.al. 10070163 [2] “A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons.” Chuang J.Z.et.al. 10191309 [3] “Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.” Wiemann S.et.al. 11230166 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers.” Suh K.S.et.al. 17200346 [6] “CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation.” Suh K.S.et.al. 17636002 [7] “CLIC4 interacts with histamine H3 receptor and enhances the receptor cell surface expression.” Maeda K.et.al. 18302930 | |
Structure: | |
External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MALSMPLNGL KEEDKEPLIE LFVKAGSDGE SIGNCPFSQR LFMILWLKGV VFSVTTVDLK 61: RKPADLQNLA PGTHPPFITF NSEVKTDVNK IEEFLEEVLC PPKYLKLSPK HPESNTAGMD 121: IFAKFSAYIK NSRPEANEAL ERGLLKTLQK LDEYLNSPLP DEIDENSMED IKFSTRKFLD 181: GNEMTLADCN LLPKLHIVKV VAKKYRNFDI PKEMTGIWRY LTNAYSRDEF TNTCPSDKEV 241: EIAYSDVAKR LTK