1.A.122. The Avian Encephalomyelitis Virus protein 3A (AEV-3A) Family
Avian encephalomyelitis virus (AEV) protein 3A is a membrane-interacting protein containing a stretch of 21 hydrophobic amino acyl residues. Residues 45-51, the most C-terminal hydrophobic domain, are essential for membrane integration in the ER (Liu et al. 2004) and large pore-formation (able to transport proteins). This motif within the transmembrane domain is essential for the stable interaction of the protein 3A with the ER membrane.