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1.A.122.  The Avian Encephalomyelitis Virus protein 3A (AEV-3A) Family 

Avian encephalomyelitis virus (AEV) protein 3A is a membrane-interacting protein containing a stretch of 21 hydrophobic amino acyl residues. Residues 45-51, the most C-terminal hydrophobic domain, are essential for membrane integration in the ER (Liu et al. 2004) and large pore-formation (able to transport proteins). This motif within the transmembrane domain is essential for the stable interaction of the protein 3A with the ER membrane.

References associated with 1.A.122 family:

Liu, J., T. Wei, and J. Kwang. (2004). Membrane-association properties of avian encephalomyelitis virus protein 3A. Virology 321: 297-306. 15051389