TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.A.126.1.1









Mitochondrial membrane Mpv17 (also called MAL and VIP17) protein of 176 aas and 4 TMSsv (Magyar et al. 1997).

Eukaryota
Metazoa
Mpv17 of Homo sapiens
1.A.126.1.2









Mpv17 domain protein of 197 aas and 4 TMSs, Sym1.

Eukaryota
Fungi
Sym1 of Saccharomyces cerevisiae
1.A.126.1.3









Peroxisomal membrane protein, Pmp22 or Pxmp2 of 195 aas and 4 TMSs.  Seems to be involved in pore-formation and may contribute to the non-specific permeability of the peroxisomal membrane although this has been questioned (Egawa et al. 2009).

Eukaryota
Metazoa
Pxmp2 of Homo sapiens
1.A.126.1.4









Mpv17 of 177 aas and 4 TMSs. It is involved in mitochondrial homeostasis, and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance (Martorano et al. 2019). It is a non-selective cation channel that modulates the membrane potential under normal conditions as well as conditions of oxidative stress (See TC# 1.A.126.1.5).

Eukaryota
Opisthokonta
Mpv17 of Danio rerio (Zebrafish) (Brachydanio rerio)
1.A.126.1.5









Mpv17 of 176 aas and 4 TMSs. It is a non-selective cation channel that modulates the membrane potential under normal conditions as well as conditions of oxidative stress (Antonenkov et al. 2015). It has a pore diameter of 1.8 nm, located the channel's selectivity filter. The channel is weakly cation-selective and shows several subconductance states. Voltage-dependent gating of the channel is regulated by redox conditions and pH and is affected also in mutants mimicking a phosphorylated state. Likewise, the mitochondrial membrane potential (Δψm) and the cellular production of reactive oxygen species were higher in embryonic fibroblasts from Mpv17(-/-) mice. However, despite the elevated Δψm, the Mpv17-deficient mitochondria showed signs of accelerated fission. These observations uncover the role of MPV17 as a Δψm-modulating channel that apparently contributes to mitochondrial homeostasis.

Eukaryota
Opisthokonta
Mpv17 of Mus musculus
1.A.126.1.6









PXMP2/4 family protein, 4-like of 264 aas and 4 - 6 TMSs.

Eukaryota
Viridiplantae
PXMP2/4 protein of Gossypium raimondii
1.A.126.1.7









Glomerulosclerosis Mpv17 of 249 aas and 4 TMSs.

Eukaryota
Opisthokonta
Mpv17 of Fusarium mexicanum
1.A.126.1.8









Uncharacterized protein of 314 aas and 4 TMSs.

Eukaryota
Sar
UP of Thalassiosira pseudonana
1.A.126.1.9









Uncharacterized protein of 293 aas and 5 - 7 TMSs, with four distinct hydrophobic peaks in the C-terminal half of the protein plus 1 - 3 TMSs in the N-terminal half.

Eukaryota
Viridiplantae
UP of Chlorella variabilis
1.A.126.1.10









Mitogen-activated protein kinase 1 with an N-terminal Mpv17 domain preceding the C-terminal kinase domain of 911 aas and 5 - 7 TMSs in the N-terminal domain.

Eukaryota
Sar
Mpv17- protein kiinase protein of Symbiodinium microadriaticum
1.A.126.1.11









Uncharacterized protein of 287 aas with a 150 aas N-terminal hydrophilic domain and a C-terminal Mpv17 domain with 4 TMSs.

Eukaryota
Opisthokonta
UP of Medioppia subpectinata
1.A.126.1.12









Uncharacterized protein of 268 aas and 5 TMSs, one N-terminal, followed by a 120 residues hydrophilic domain followed by the 4 TMS Mpv17 domain.

Eukaryota
Haptista
UP of Chrysochromulina tobinii