TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
1.A.126.1.1 | Mitochondrial membrane Mpv17 (also called MAL and VIP17) protein of 176 aas and 4 TMSsv (Magyar et al. 1997). | Eukaryota |
Metazoa, Chordata | Mpv17 of Homo sapiens |
1.A.126.1.2 | Mpv17 domain protein of 197 aas and 4 TMSs, Sym1. | Eukaryota |
Fungi, Ascomycota | Sym1 of Saccharomyces cerevisiae |
1.A.126.1.3 | Peroxisomal membrane protein, Pmp22 or Pxmp2 of 195 aas and 4 TMSs. Seems to be involved in pore-formation and may contribute to the non-specific permeability of the peroxisomal membrane although this has been questioned (Egawa et al. 2009). | Eukaryota |
Metazoa, Chordata | Pxmp2 of Homo sapiens |
1.A.126.1.4 | Mpv17 of 177 aas and 4 TMSs. It is involved in mitochondrial homeostasis, and control of oxidative phosphorylation and mitochondrial DNA (mtDNA) maintenance (Martorano et al. 2019). It is a non-selective cation channel that modulates the membrane potential under normal conditions as well as conditions of oxidative stress (See TC# 1.A.126.1.5). | Eukaryota |
Metazoa, Chordata | Mpv17 of Danio rerio (Zebrafish) (Brachydanio rerio) |
1.A.126.1.5 | Mpv17 of 176 aas and 4 TMSs. It is a non-selective cation channel that modulates the membrane potential under normal conditions as well as conditions of oxidative stress (Antonenkov et al. 2015). It has a pore diameter of 1.8 nm, located the channel's selectivity filter. The channel is weakly cation-selective and shows several subconductance states. Voltage-dependent gating of the channel is regulated by redox conditions and pH and is affected also in mutants mimicking a phosphorylated state. Likewise, the mitochondrial membrane potential (Δψm) and the cellular production of reactive oxygen species were higher in embryonic fibroblasts from Mpv17(-/-) mice. However, despite the elevated Δψm, the Mpv17-deficient mitochondria showed signs of accelerated fission. These observations uncover the role of MPV17 as a Δψm-modulating channel that apparently contributes to mitochondrial homeostasis. | Eukaryota |
Metazoa, Chordata | Mpv17 of Mus musculus |
1.A.126.1.6 | PXMP2/4 family protein, 4-like of 264 aas and 4 - 6 TMSs. | Eukaryota |
Viridiplantae, Streptophyta | PXMP2/4 protein of Gossypium raimondii |
1.A.126.1.7 | Glomerulosclerosis Mpv17 of 249 aas and 4 TMSs. | Eukaryota |
Fungi, Ascomycota | Mpv17 of Fusarium mexicanum |
1.A.126.1.8 | Uncharacterized protein of 314 aas and 4 TMSs. | Eukaryota |
Bacillariophyta | UP of Thalassiosira pseudonana |
1.A.126.1.9 | Uncharacterized protein of 293 aas and 5 - 7 TMSs, with four distinct hydrophobic peaks in the C-terminal half of the protein plus 1 - 3 TMSs in the N-terminal half. | Eukaryota |
Viridiplantae, Chlorophyta | UP of Chlorella variabilis |
1.A.126.1.10 | Mitogen-activated protein kinase 1 with an N-terminal Mpv17 domain preceding the C-terminal kinase domain of 911 aas and 5 - 7 TMSs in the N-terminal domain. | Eukaryota |
Mpv17- protein kiinase protein of Symbiodinium microadriaticum | |
1.A.126.1.11 | Uncharacterized protein of 287 aas with a 150 aas N-terminal hydrophilic domain and a C-terminal Mpv17 domain with 4 TMSs. | Eukaryota |
Metazoa, Arthropoda | UP of Medioppia subpectinata |
1.A.126.1.12 | Uncharacterized protein of 268 aas and 5 TMSs, one N-terminal, followed by a 120 residues hydrophilic domain followed by the 4 TMS Mpv17 domain. | Eukaryota |
Haptophyta | UP of Chrysochromulina tobinii |