1.A.13.1.7
xCLCA3; xCLCA2 of 942 aas and 7 TMSs. xCLCA3 contains a predicted signal sequence, multiple
sites of N-linked glycosylation, N-myristoylation, PKA, PKC, and casein kinase II
phosphorylation sites, five putative hydrophobic segments, and the HExxH metalloprotease motif.
Additionally, the transmembrane prediction server yielded a preserved N-terminal CLCA domain and a
von Willebrand factor type A domain with one transmembrane domain in the C-terminal region (Lee and Jeong 2016).
xCLCA3 is expressed in a number of tissues, with strong expression
in the brain, colon, small intestine, lung, kidney, and spleen, and poor expression in the heart and
liver. xCLCA3 may be a candidate CLCA family member as well as a
metalloprotease, rather than just an ion channel accessory protein.
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| Accession Number: | F7IYU5 |
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| Protein Name: | Calcium activated chloride channel |
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| Length: | 942 |
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| Molecular Weight: | 103214.00 |
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| Species: | Xenopus laevis (African clawed frog) [8355] |
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| Number of TMSs: | 1 |
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| Substrate |
chloride |
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1: MTFSSLFALV LTFHVFFASS TSIKLQNGGY EDIVIAINPG LRENFKIIEN IQNMIKDATP
61: YLFSATRNRV YIRSVKILIP ITWPNKNYTK ARTETYDKAD VIIASPHVKF GDDPYTLQYG
121: GCGEPGKYIH MTPDFFLDDN LISIYGPRGR VFVHEWAHLR WGVFDEYNYE KPFYVTGTKN
181: IEATRCSADI IGTYMKLCQG RICNCIRDPQ TGLYEDGCVF VPERNQAAKS SIMYSQALPS
241: VTEFCEKNHN TEAPTLQNRI CNSRSTWDVI MNSTDIKSTP PKADSNLPVP TFSLLQSSDR
301: VVTLVLDVSG SMTSGDRIGR LYQAAEVFVM QIVEEGSHVG IVTFSTTTAV LSKLVQVIDD
361: TQRNKLKRLL PKTATGGTDI CKGIREGIKL NKEHDGSSSN TELVLLTDGE DNYDTSLCFP
421: DIKNSGAIIH FIALGPKPAT KLEQIVEMTG GLRFLATDKV DALGLIDAFS SLKAGDGATS
481: QHAIQLESSG SILKPKNCLT GTVFIDKTVG NGTFFLVTWV TLVPSITLID PNGKVYTSKD
541: FTSDTTSKSS RLKIPGTAER GAWQYNLCNN HTANQAIGIL VTSMAADENV PPITVNAHMN
601: RDNNNFPEPM IVYASVNQGL LPVVNANVTA IIEPVNGKSV PLELYDNGAG VDIVKNDGIY
661: SGYFFEFQGN GRYSLKVRVE NSKKKSRLAL PRSRALYIPG YLENGQITMN PSRPVINDED
721: FYLGEFSRTA SGGSFIVNNI PPGVQPDLYK PEKVTDLEAK IEGNTIVLTW TATGDDLDKG
781: TVSGYDLRMN TNPSDLRNNF DNSTTVNTSS LMPQIAGSSE SFTFVPNNIA IENGTILYFA
841: LTAFDKVAHK SDLSNIAQAA LLIPPTPAPT TVQPLPASTT VQKTPAPTTV LPPSSDDSSG
901: TLDITFLTMI VCSSVIIICI IISITVCIVN CRKKKRNPEI RP