| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
1.A.13.1.1 | Voltage-gated bovine epithelial Cl- channel protein (Ca2+-activated), bEClC. In rats, two possible paralogues (rbCLCA1 and A2) are expressed in the CNS and peripheral organs (Yoon et al., 2006). CLCA1 may play a role in inflammatory airway diseases (Sala-Rabanal et al. 2015). It is called the von Willebrand factor type A, the DUF1973 protein. | Eukaryota |
Metazoa, Chordata | EClC of Bos taurus (NP_001070824) |
|
1.A.13.1.2 | Ca2+-activated Cl- channel-2, CaCC-2 | Eukaryota |
Metazoa, Chordata | CaCC-2 of Homo sapiens |
|
1.A.13.1.3 | The Ca-activated chloride channel-6 (Lee et al., 2011). | Eukaryota |
Metazoa, Chordata | Ca-CLC-6 of Xenopus laevis (F7IYU6) |
|
1.A.13.1.4 | Calcium-activated chloride channel regulator family member 3 (Calcium-activated chloride channel family member 3) (hCLCA3) | Eukaryota |
Metazoa, Chordata | CLCA3P of Homo sapiens |
|
1.A.13.1.5 | Putative lipoprotein of 1054 aas and 1-3 TMSs. | Bacteria |
Spirochaetota | Putative lipoprotein of Leptospira biflexa |
|
1.A.13.1.6 | Ca+2-activated Cl- channel, or Chloride Channel Accessory 1 (CLCA1 or CACC1), of 914 aas. CLCA1 may play a role in inflammatory airway diseases (Sala-Rabanal et al. 2015). It is thought to play a role in Cl- secretion in the intestine (A. Quach, personal communication). Airway mucus hypersecretion is a clinical feature of a number of childhood diseases, including asthma and bronchitis-associated conditions (Rogers 2003). Clca1-deficient (Clca1(-/-)) mice displayed compromised mucus layer integrity, reduced neutrophil infiltration, and gut microbiota dysbiosis. CLCA1 and ZG16 are lowly expressed in colorectal cancer (CRC), and they could be prognostic biomarkers for the malignant progression of CRC Sala-Rabanal et al. 2015). It is thought to play a role in Cl- secretion in the intestine (A. Quach, personal communication). Airway mucus hypersecretion is a clinical feature of a number of childhood diseases, including asthma and bronchitis-associated conditions (Rogers 2003). Clca1-deficient (Clca1(-/-)) mice displayed compromised mucus layer integrity, reduced neutrophil infiltration, and gut microbiota dysbiosis. CLCA1 and ZG16 are lowly expressed in colorectal cancer (CRC), and they could be prognostic biomarkers for the malignant progression of CRC (Zhang et al. 2025). | Eukaryota |
Metazoa, Chordata | CLCA1 of Homo sapiens |
|
1.A.13.1.7 | xCLCA3; xCLCA2 of 942 aas and 7 TMSs. xCLCA3 contains a predicted signal sequence, multiple sites of N-linked glycosylation, N-myristoylation, PKA, PKC, and casein kinase II phosphorylation sites, five putative hydrophobic segments, and the HExxH metalloprotease motif. Additionally, the transmembrane prediction server yielded a preserved N-terminal CLCA domain and a von Willebrand factor type A domain with one transmembrane domain in the C-terminal region (Lee and Jeong 2016). xCLCA3 is expressed in a number of tissues, with strong expression in the brain, colon, small intestine, lung, kidney, and spleen, and poor expression in the heart and liver. xCLCA3 may be a candidate CLCA family member as well as a metalloprotease, rather than just an ion channel accessory protein. | Eukaryota |
Metazoa, Chordata | xCLCA3 of Xenopus laevis (African clawed frog) |
|
1.A.13.1.8 | VWFA domain-containing protein, CLCA1 of 935 aas and 2 TMSs, N- and C-terminal, and possibly one that is centrally located. The galline CLCA1 displays close genetic distances to mammalian clusters 1, 3 and 4 (Bartenschlager et al. 2022). | Eukaryota |
Metazoa, Chordata | CLCA1 of Gallus gallus (Chicken) |
|
1.A.13.1.9 | VWFA domain-containing protein, CLCA2, chloride-transporting anion channel, regulated by calcium ions, of 1005 aas and 2 TMSs, one N-terminal and one C-terminal (Bartenschlager et al. 2022). | Eukaryota |
Metazoa, Chordata | CLCA2 of Gallus gallus (Chicken) |
|
1.A.13.1.10 | Calcium-activated chloride channel, CLCA2 regulator-2 of 943 aas and 2 TMSs, N- and C-terminal. CLCA2 overexpression suppresses epithelial-to-mesenchymal transition in cervical cancer cells through inactivation of ERK/JNK/p38-MAPK signaling pathways (Xin et al. 2022). Transport of CLCA2 to the nucleus by extracellular vesicles controls keratinocyte survival and migration (Seltmann et al. 2024). | Eukaryota |
Metazoa, Chordata | CLCA2 of Homo sapiens |
|
1.A.13.2.1 | Hypothetical protein, HP | Eukaryota |
Viridiplantae, Streptophyta | HP of Oryza sativa (B8AFH9) |
|
1.A.13.2.2 | Sll0103 | Bacteria |
Cyanobacteriota | Sll0103 of Synechocystis (Q55874) |
|
1.A.13.2.3 | The YfbK/CaClC homologue of 575aas and 0 TMSs. YfbK has amyloidogenic regions due to asparagine- and glutamine-rich regions which is a common feature of many known amyloid proteins. This correlates with detergent-induced denaturation resistance (Antonets et al. 2016). | Bacteria |
Pseudomonadota | YfbK of E. coli (P76481) |
|
1.A.13.2.4 | Von Willebrand factor type A domain protein of 536 aas and 1 N-terminal TM | Bacteria |
Planctomycetota | Von Willebrand factor of Tuwongella immobilis |
|
1.A.13.3.1 | Von Willebrand factor type A protein, vWFA. (905 aas; 2 N-terminal and 1 C-terminal TMSs) | Bacteria |
Chloroflexota | vWFA of Chloroflexus aurantiacus (A9WIT9) |
|
1.A.13.4.1 | Bacterial homologue, BatB, of mammalian Ca-CLC channels (N- and C-terminal TMSs) | Bacteria |
Myxococcota | BatB of Myxococcus fulvus (F8CM01) |
|
1.A.13.4.2 | von Willebrand factor type A domain protein, BabT, of 340 aas and 3 TMSs, N- and C-terminal as well as at residue 60. | Bacteria |
Pseudomonadati, Bacteroidota | von Willebrand factor type A of Hoylesella ovalis |
|
1.A.13.4.3 | von Willebrand factor type A of 346 aas and 3 TMSs, N- and C-terninal and at ~ residue 60. | Bacteria |
Pseudomonadati, Chlorobiota | von Willebrand factor of Chloroherpeton thalassium |
|
1.A.13.5.1 | Putative glutamine amidotransferase domain-containing protein of 252 aas and 2-3 TMSs. | Bacteria |
Pseudomonadota | Gln amidotransferase domain protein of E. coli |