TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.A.13.1.1









Voltage-gated bovine epithelial Cl- channel protein (Ca2+-activated), bEClC. In rats, two possible paralogues (rbCLCA1 and A2) are expressed in the CNS and peripheral organs (Yoon et al., 2006). CLCA1 may play a role in inflammatory airway diseases (Sala-Rabanal et al. 2015). It is called the von Willebrand factor type A, the DUF1973 protein.

Eukaryota
Metazoa
EClC of Bos taurus (NP_001070824)
1.A.13.1.2









Ca2+-activated Cl- channel-2, CaCC-2
Eukaryota
Metazoa
CaCC-2 of Homo sapiens
1.A.13.1.3









The Ca-activated chloride channel-6 (Lee et al., 2011).

Eukaryota
Metazoa
Ca-CLC-6 of Xenopus laevis (F7IYU6)
1.A.13.1.4









Calcium-activated chloride channel regulator family member 3 (Calcium-activated chloride channel family member 3) (hCLCA3)
Eukaryota
Metazoa
CLCA3P of Homo sapiens
1.A.13.1.5









Putative lipoprotein of 1054 aas and 1-3 TMSs.

Bacteria
Spirochaetes
Putative lipoprotein of Leptospira biflexa
1.A.13.1.6









Ca+2-activated Cl- channel, or Chloride Channel Accessory 1 (CLCA1 or CACC1), of 914 aas.  CLCA1 may play a role in inflammatory airway diseases (Sala-Rabanal et al. 2015). It is thought to play a roleSala-Rabanal et al. 2015). It is thought to play a role in Cl- secretion in the intestine (A. Quach, personal communication).

Eukaryota
Metazoa
CLCA1 of Homo sapiens
1.A.13.1.7









xCLCA3; xCLCA2 of 942 aas and 7 TMSs.  xCLCA3 contains a predicted signal sequence, multiple sites of N-linked glycosylation, N-myristoylation, PKA, PKC, and casein kinase II phosphorylation sites, five putative hydrophobic segments, and the HExxH metalloprotease motif. Additionally, the transmembrane prediction server yielded a preserved N-terminal CLCA domain and a von Willebrand factor type A domain with one transmembrane domain in the C-terminal region (Lee and Jeong 2016). xCLCA3 is expressed in a number of tissues, with strong expression in the brain, colon, small intestine, lung, kidney, and spleen, and poor expression in the heart and liver. xCLCA3 may be a candidate CLCA family member as well as a metalloprotease, rather than just an ion channel accessory protein.

Eukaryota
Metazoa
xCLCA3 of Xenopus laevis (African clawed frog)
1.A.13.2.1









Hypothetical protein, HP

Eukaryota
Viridiplantae
HP of Oryza sativa (B8AFH9)
1.A.13.2.2









Sll0103

Bacteria
Cyanobacteria
Sll0103 of Synechocystis (Q55874)
1.A.13.2.3









The YfbK/CaClC homologue of 575aas and 0 TMSs.  YfbK has amyloidogenic regions due to asparagine- and glutamine-rich regions which is a common feature of many known amyloid proteins. This correlates with detergent-induced denaturation resistance (Antonets et al. 2016).

Bacteria
Proteobacteria
YfbK of E. coli (P76481)
1.A.13.2.4









Von Willebrand factor type A domain protein of 536 aas and 1 N-terminal TM

Bacteria
Planctomycetes
Von Willebrand factor of Tuwongella immobilis
1.A.13.3.1









Von Willebrand factor type A protein, vWFA. (905 aas; 2 N-terminal and 1 C-terminal TMSs)

Bacteria
Chloroflexi
vWFA of Chloroflexus aurantiacus (A9WIT9)
1.A.13.4.1









Bacterial homologue, BatB, of mammalian Ca-CLC channels (N- and C-terminal TMSs)

Bacteria
Proteobacteria
BatB of Myxococcus fulvus (F8CM01)
1.A.13.5.1









Uncharacterized protein of 252 aas and 2-3 TMSs

Bacteria
Proteobacteria
UP of E. coli