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1.A.131.1.2
TRP-like ion channel PKD2 (Polycystic kidney disease-related ion channel 2).  It regulates cytoplasmic calcium ion concentrations (Ma et al. 2011). The functions of Pkd2 include playing roles in cell wall synthesis, membrane protein trafficking and regulating cell separation during cytokinesis (Aydar and Palmer 2009; Morris et al. 2019). The protein has 710 aas and 9 TMSs in a 1 (N-terminus) + 1 (at residue 180) +3 (residues 320 - 420) + 4 (residues 470 - 580).

Accession Number:Q09917
Protein Name:TRP-like ion channel pkd2
Length:710
Molecular Weight:79989.00
Species:Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) [284812]
Number of TMSs:9
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 2541613   
Pfam: PF06011   
KEGG: spo:SPAC1F7.03   

Gene Ontology

GO:0005783 C:endoplasmic reticulum
GO:0030173 C:integral to Golgi membrane
GO:0005887 C:integral to plasma membrane
GO:0031520 C:plasma membrane of cell tip
GO:0005262 F:calcium channel activity
GO:0070509 P:calcium ion import
GO:0071433 P:cell wall repair
GO:0006874 P:cellular calcium ion homeostasis
GO:0090002 P:establishment of protein localization in plasma membrane
GO:0009272 P:fungal-type cell wall biogenesis
GO:0031505 P:fungal-type cell wall organization
GO:0017157 P:regulation of exocytosis
GO:0032995 P:regulation of fungal-type cell wall biogenesis
GO:0033157 P:regulation of intracellular protein transport

References (3)

[1] “The genome sequence of Schizosaccharomyces pombe.”  Wood V.et.al.   11859360
[2] “A microbial TRP-like polycystic-kidney-disease-related ion channel gene.”  Palmer C.P.et.al.   15537393
[3] “Phosphoproteome analysis of fission yeast.”  Wilson-Grady J.T.et.al.   18257517

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MRLWRSPLLL LVVVVELFSW ADALTRFISA DSLSTCMTDS QLSASKLYAS YFPDNQSVAF 
61:	DISIQSLVST NVSIDVDISA YGIEIKKVID PCDMEISGFC PMQTGNIALS GSHTLTGEAL 
121:	SILDSIPSIA YTVPDLDAVV TINIYESDTN TQLACVRTTV QNGRSVYHRA VYWVMCMVIG 
181:	IPLLIFLLIS PVLQTPALWE IVETMITLFQ FAQIQALYSM MATSLPAIIY SWGRNFMWSM 
241:	GIIRIGFMQD VFTWYVKSTG GTPSTLVDLG IHANVALAKR GIDLGSLAKR ATTTVTTSTS 
301:	DSITLRGIKR ISYMMGIETT NFFATGFSFF IILLFFSLLV AMASRFIVEM VLLASRNQAL 
361:	KKQRIRLYWK SISKGFFYRV IFVGFTQMSV LSMWEIYTRD SSALAFLSMY VIVDMAVLLC 
421:	YAFVRTIQII RKTGPYSHPD VLYNLYSDTQ HLMRWGFMYV QLDVRFFYFT FPLLLITLVR 
481:	SMFIGFGQGS PKVQGCAMFG ISVVVFALMV ILRPYATKHM NTLHIGVALM NLISGSFILV 
541:	MCQAFYVEEL ARQVIGIIFF ALNAITMLLL ILGIFIRTLI VLFRKSGHGT YYRILDDQSE 
601:	KATSYNKSIK DMSSSDMAFS DPAYSGTTLR SSVDLNTPEY PFSNRNDSDS TFTNNKYVSP 
661:	WDAIEEASYA NLRGNTDVEQ PFMESDYTRI SENNNNAERR RKPLPNNAFR