TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
---|---|---|---|---|
1.A.133.1.1 | The Csx28 pore-forming protein of 177 aas with 1 N-terminal TMS and possibly a second moderately hydrkophhobic region between residues 100 - 140. It transports ions and colapses the inner membrane potential (pmf) by allowing the free flow of ions, possiblly inorganic cations, across the membrane. It has an octomeric structure with a well ordered C-terminal domain (VanderWal et al. 2023). The pore diameter is ~ 10 Å; each protomer is a 4-helix bundle (α1 to α4) where α1 and α2 form the inner lining of the pore and the two C-terminal helices form the outer surface of the pore. Cas13b senses the viral transcript and signals to Csx28. | Bacteria |
Bacteroidota | Csx28 of Prevotella buccae |
1.A.133.1.2 | Uncharacterized protein of 178 aas with 1 N-terminal TMS. | Bacteria |
Cyanobacteriota | UP of Leptolyngbya sp. |
1.A.133.1.3 | Uncharacterized protein of 195 aas and 1 N-terminal TMS plus three more moderate peaks of hydrophobicity, where the degree of hydrophobicity is TMS1 > 2 > 3 > 4. | Bacteria |
Bacteroidota | UP of Chitinophagales bacterium (activated sludge metagenome) |
1.A.133.1.4 | CRISPR-associated protein Csx28 OF 211 aas and kone strongly hydrophobic N-terminal TMS followed by two much less hydrophobic peaks that may be TMSs. | Bacteria |
Bacteroidota | Csx28 of Phaeodactylibacter xiamenensis |
1.A.133.1.5 | Uncharacterized protein of 181 aas and 1 N-terminal TMS followed by three peaks of low degrees of hydrophobicity. | Bacteria |
Pseudomonadota | UP of Salmonella enterica |
1.A.133.1.6 | Uncharacterized protein of 172 aas and 1 N-terminal TMS | Bacteria |
Pseudomonadota | UP of Colwellia sp. (invertebrate metagenome) |
1.A.133.1.7 | Uncharacterized protein of 163 aas and 1 N-terminal TMS. | Bacteria |
Chloroflexota | UP of Anaerolineales bacterium (activated sludge metagenome) |
1.A.133.1.8 | Uncharacterized protein of 231 aas and 1 N-terminal TMS. | Bacteria |
Actinomycetota | UP of Actinobacteria bacterium OV450 |
1.A.133.1.9 | Uncharacterized protein of 187 aas and 1 N-terminal TMS. | Bacteria |
Actinomycetota | UP of Kutzneria sp. CA-103260 |