TCDB is operated by the Saier Lab Bioinformatics Group
TCIDNameDomainKingdom/PhylumProtein(s)
1.A.133.1.1









The Csx28 pore-forming protein of 177 aas with 1 N-terminal TMS and possibly a second moderately hydrkophhobic region between residues 100 - 140.  It transports ions and colapses the inner membrane potential (pmf) by allowing the free flow of ions, possiblly inorganic cations, across the membrane. It has an octomeric structure with a well ordered C-terminal domain (VanderWal et al. 2023). The pore diameter is ~ 10 Å; each protomer is a 4-helix bundle (α1 to α4) where α1 and α2 form the inner lining of the pore and the two C-terminal helices form the outer surface of the pore. Cas13b senses the viral transcript and signals to Csx28.

Bacteria
Bacteroidota
Csx28 of Prevotella buccae
1.A.133.1.2









Uncharacterized protein of 178 aas with 1 N-terminal TMS.

Bacteria
Cyanobacteriota
UP of Leptolyngbya sp.
1.A.133.1.3









Uncharacterized protein of 195 aas and 1 N-terminal TMS plus three more moderate peaks of hydrophobicity, where the degree of hydrophobicity is TMS1 > 2 > 3 > 4.

Bacteria
Bacteroidota
UP of Chitinophagales bacterium (activated sludge metagenome)
1.A.133.1.4









CRISPR-associated protein Csx28 OF 211 aas and kone strongly hydrophobic N-terminal TMS followed by two much less hydrophobic peaks that may be TMSs.

Bacteria
Bacteroidota
Csx28 of Phaeodactylibacter xiamenensis
1.A.133.1.5









Uncharacterized protein of 181 aas and 1 N-terminal TMS followed by three peaks of low degrees of hydrophobicity.

Bacteria
Pseudomonadota
UP of Salmonella enterica
1.A.133.1.6









Uncharacterized protein of 172 aas and 1 N-terminal TMS

Bacteria
Pseudomonadota
UP of Colwellia sp. (invertebrate metagenome)
1.A.133.1.7









Uncharacterized protein of 163 aas and 1 N-terminal TMS.

Bacteria
Chloroflexota
UP of Anaerolineales bacterium (activated sludge metagenome)
1.A.133.1.8









Uncharacterized protein of 231 aas and 1 N-terminal TMS.

Bacteria
Actinomycetota
UP of Actinobacteria bacterium OV450
1.A.133.1.9









Uncharacterized protein of 187 aas and 1 N-terminal TMS.

Bacteria
Actinomycetota
UP of Kutzneria sp. CA-103260