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1.A.144.  The A15.5L Viroporin (A15.5L-VP) Family

This family has been examined, first, showing that its characterized member is a  small transmembrane protein of 73 aas and 1 TMS (residues 45 - 69). Second, it has been shown to have ion channel activity (Basu et al. 2023). Third, its 3-D transmembrane structure has been predicted using alpha-fold.

References associated with 1.A.144 family:

Basu, K., M. Krugliak, and I.T. Arkin. (2023). Viroporins of Mpox Virus. Int J Mol Sci 24:. 37762131
McGilvray, P.T., S.A. Anghel, A. Sundaram, F. Zhong, M.J. Trnka, J.R. Fuller, H. Hu, A.L. Burlingame, and R.J. Keenan. (2020). An ER translocon for multi-pass membrane protein biogenesis. Elife 9:. 32820719