1.A.16.2.7
FNT protein of 313 aas and 6 TMSs that transports L-lactacte (Wiechert et al. 2017). Trophozoites are inhibited by drugs such as MMVOO7839 (Golldack et al. 2017, Hapuarachchi et al. 2017). It seems to transport lactic acid which allows concentrative uptake (Bader and Beitz 2020). However, it exports lactate from inside the parasite to the surrounding parasitophorous vacuole within the erythrocyte cytosol (Lyu et al. 2021).
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| Accession Number: | SCP04225.1 |
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| Protein Name: | SCP04225.1 formate-nitrite transporter, putative [Plasmodium falciparum] |
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| Length: | 314 |
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| Molecular Weight: | |
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| Species: | Plasmodium falciparum [5833] |
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| Number of TMSs: | 6 |
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| Substrate |
lactate |
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1: MPKSNTKYVI DPLSVKTSCS SEESYIRCVE YGKSKAHYSS LILLAKAILA GVFVGVCAHA
61: SGIAGGLFYY HKLREYVGAS MSAFVYGFTF PIAFLCIICT GSDLFTGNTL AVTTALLHGK
121: VSCLEYVRVM CISLFGNYVG AVSFAFFVSY GSGAFHKKEQ VDKNHIFQFL NDIAVKKVNH
181: TFVECICLAI GCNIFVCLAV YFVLSIKDGS GMVFSVFFAV YAFAIAGYEH IIANIYTLNI
241: SLMIDTEVSF TQVYFKNLLP TLIGNYIAGA LVLACPLFFI YRSYYINYEK MNEPSGGSLR
301: SISIEMKNDG GAT