1.A.16.2.9
Lactate/formate/nitrate antiporter, or lactate:H+ symporter, FNT, possibly energized by the pmf. It is similar to 1.A.16.2.7, two proteins that are are 74% identical to each other). 3-D structures have been elucidated (PDB# 7E26 and 7E27). It is essential and druggable In vivo (Davies et al. 2023).
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| Accession Number: | O77389 |
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| Protein Name: | Formate-nitrite transporter |
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| Length: | 309 |
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| Molecular Weight: | 34458.00 |
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| Species: | Plasmodium falciparum (isolate 3D7) [36329] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
lactate, formate, nitrate |
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1: MPPNNSKYVL DPVSIKSVCG GEESYIRCVE YGKKKAHYSN LNLLAKAILA GMFVGLCAHA
61: SGIAGGLFYY HKLREIVGAS MSVFVYGFTF PIAFMCIICT GSDLFTGNTL AVTMALYEKK
121: VKLLDYLRVM TISLFGNYVG AVSFAFFVSY LSGAFTNVHA VEKNHFFQFL NDIAEKKVHH
181: TFVECVSLAV GCNIFVCLAV YFVLTLKDGA GYVFSVFFAV YAFAIAGYEH IIANIYTLNI
241: ALMVNTKITV YQAYIKNLLP TLLGNYIAGA IVLGLPLYFI YKEHYYNFER SKRDNNDAQM
301: KSLSIELRN