1.A.17.1.17
TMEM16 (Ist2) ion channel/phospholipid scramblase of 735 aas and 8 - 10 TMSs (Malvezzi et al. 2013). Three high-resolution cryo-EM structures of this scramblase, reconstituted in lipid nanodiscs, revealed that Ca2+-dependent activation of the scramblase entails global rearrangement of the transmembrane and cytosolic domains. Activation of the protein thins the membrane near the transport pathway to facilitate rapid transbilayer lipid movement (Falzone et al. 2019).
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| Accession Number: | B0YES0 |
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| Protein Name: | Plasma membrane channel protein Ist2, putative |
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| Length: | 735 |
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| Molecular Weight: | 84544.00 |
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| Species: | Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) [451804] |
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| Number of TMSs: | 7 |
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| Substrate |
ion, phospholipid |
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1: MAFNPAPKAV QENHHVDYVI RFNYGDIDTP EAIKKFEVLL LELSEVGLQT EVRQGDENSL
61: FVFVRAASKK KLKRAVYQSR VRDWLYGVRN TEPEPASSAK PQSEAERLRV IYHLITVPKA
121: EGGAGITPRH GEWKNVDAIF PLHDEETNRQ CMREWSKKTF LSTEDLDRIR NTFGEHVGFY
181: FAFLQSYFRF LMFPAAFGFS CWLLLGSFSI IYTVVNCLWC IVFIEYWKRQ EEDLSCRWQT
241: KGVSAVHEKR AEFKPEKEIR DESTGEVRGV FPATKRMYRQ LLQVPFALLA AVALGAIIAT
301: CFAIEIFISE VYNGPLKGYL VFIPTILVSA LIPTMSAVLL TVATKLNDYE NYETQDAYKV
361: ALTQKIFVVN FITSYLPIIL TAFVYVPFAS RIVPYLDVFH LTVRPFVSKE HATKARTEFS
421: INPDRLRKQV IYFTVTAQIV GFALETIVPF VKQRVFREYK EYTKKQHAKA EPGNGAGEKK
481: TVSLGDDEDE ARFLTRVRNE AELEDYDVTD DLREMCIQFG YLALFSPVWP LVPVSFLINN
541: WVELRSDFFK ICVECKRPWP QRADTIGPWL DSLGFLSWVG SITSSALVYM FSNGHEGPNG
601: EPTTIRCWAL LLTIFFSEHL YLIVRYAVRS ALAKLEPPNT RRERIERFMM RKRYLDTVLS
661: AESDDDADEV KGVVSSIPPS EITRESLEQD ARDWSKQGTD PTERFWMRQR GWKESAEVGL
721: SLITKAKGDE TKKQQ