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1.A.17.1.17
TMEM16 (Ist2) ion channel/phospholipid scramblase of 735 aas and 8 - 10 TMSs (Malvezzi et al. 2013).  Three high-resolution cryo-EM structures of this scramblase, reconstituted in lipid nanodiscs, revealed that Ca2+-dependent activation of the scramblase entails global rearrangement of the transmembrane and cytosolic domains. Activation of the protein thins the membrane near the transport pathway to facilitate rapid transbilayer lipid movement (Falzone et al. 2019).  

Accession Number:B0YES0
Protein Name:Plasma membrane channel protein Ist2, putative
Length:735
Molecular Weight:84544.00
Species:Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) [451804]
Number of TMSs:7
Substrate ions, phospholipids

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MAFNPAPKAV QENHHVDYVI RFNYGDIDTP EAIKKFEVLL LELSEVGLQT EVRQGDENSL 
61:	FVFVRAASKK KLKRAVYQSR VRDWLYGVRN TEPEPASSAK PQSEAERLRV IYHLITVPKA 
121:	EGGAGITPRH GEWKNVDAIF PLHDEETNRQ CMREWSKKTF LSTEDLDRIR NTFGEHVGFY 
181:	FAFLQSYFRF LMFPAAFGFS CWLLLGSFSI IYTVVNCLWC IVFIEYWKRQ EEDLSCRWQT 
241:	KGVSAVHEKR AEFKPEKEIR DESTGEVRGV FPATKRMYRQ LLQVPFALLA AVALGAIIAT 
301:	CFAIEIFISE VYNGPLKGYL VFIPTILVSA LIPTMSAVLL TVATKLNDYE NYETQDAYKV 
361:	ALTQKIFVVN FITSYLPIIL TAFVYVPFAS RIVPYLDVFH LTVRPFVSKE HATKARTEFS 
421:	INPDRLRKQV IYFTVTAQIV GFALETIVPF VKQRVFREYK EYTKKQHAKA EPGNGAGEKK 
481:	TVSLGDDEDE ARFLTRVRNE AELEDYDVTD DLREMCIQFG YLALFSPVWP LVPVSFLINN 
541:	WVELRSDFFK ICVECKRPWP QRADTIGPWL DSLGFLSWVG SITSSALVYM FSNGHEGPNG 
601:	EPTTIRCWAL LLTIFFSEHL YLIVRYAVRS ALAKLEPPNT RRERIERFMM RKRYLDTVLS 
661:	AESDDDADEV KGVVSSIPPS EITRESLEQD ARDWSKQGTD PTERFWMRQR GWKESAEVGL 
721:	SLITKAKGDE TKKQQ