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| Accession Number: | Q75UR0 |
| Protein Name: | Anoctamin-5 |
| Length: | 904 |
| Molecular Weight: | 106214.00 |
| Species: | Mus musculus (Mouse) [10090] |
| Number of TMSs: | 8 |
| Location1 / Topology2 / Orientation3: | Endoplasmic reticulum membrane1 / Multi-pass membrane protein2 |
| Substrate | chloride |
Cross database links:
| RefSeq: | NP_808362.2 |
|---|---|
| Entrez Gene ID: | 233246 |
| Pfam: | PF04547 |
| KEGG: | mmu:233246 |
Gene Ontology
GO:0034707
C:chloride channel complex
GO:0005789
C:endoplasmic reticulum membrane
GO:0005254
F:chloride channel activity
GO:0006811
P:ion transport
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References (5)[1] “The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD).” Tsutsumi S.et.al. 15124103 [2] “Molecular cloning and characterization of the murine gnathodiaphyseal dysplasia gene GDD1.” Tsutsumi S.et.al. 15882990 [3] “The transcriptional landscape of the mammalian genome.” Carninci P.et.al. 16141072 [4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [5] “Molecular characterization of GDD1/TMEM16E, the gene product responsible for autosomal dominant gnathodiaphyseal dysplasia.” Mizuta K.et.al. 17418107
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MVEQEGLTAK EIDYAFQQNE NLGSKETSFL IPEDLQSPPE KRFNLFLRRR LMFQRSEHSK 61: DSVFFRDGIR QIDFVLSYVE DLKKDGELKA ERRREFEQNL RKTGLDLETE DKLNSEDGKT 121: YFVKIHAPWE VLVTYAEVLG IKMPIKLSDI PRPKYPPLSY MLGAVKLPSS VKYPTPEYFT 181: AQFSRHRQEL FLIEDEATFF PSSTRNRIVY YILSRCPFGV EEGKKKIGIE RLLNSNTYLS 241: AYPLHDGQYW KPSKTTRPNE RYNLCKNWAR FSYFYKEQPF HLIRNYFGEK IGIYFVFLGY 301: YTEMLLFAAL VGLACFIYGL LSMENNRTST EICDPDIGGQ MIMCPLCDEV CDYWRLNTTC 361: LHSKFSHLFD NESTVFFALF MGIWVTLFLE FWKQRQARLE YEWDLVDFEE EQQQLQLRPE 421: FEAMCKHKKM NPVTKEMEPH MPLCHRIPWY FVSGTTVTFG MALLLSSMVS ILIYRLSVFA 481: TFASFMESEA TLQSVKSFFT PQLATALSGS CLNCIVILIL NFFYEKISAW ITKMEIPRTH 541: QEYESSLTLK MFLFQFVNYY SSCFYVAFFK GKFVGYPGSY TYMFNIWRSE ECGPAGCLIE 601: LTTQLTIIMI GKQIFGNIHE AFQPLIFNWW RRRRARTHSE KLYSRWEQDH DLQVYGHRGL 661: FYEYLETVIQ FGFATLFVAS FPLAPLFALM NNIMGIRVDA WKLTTQYRRP VAAKAHSIGV 721: WQDILFGMAI VSVATNAFIV SFTSDIIPRL VYFYAYSTNS TEPLSGYVNN SLSVFLIADF 781: PNHTVPMEKK DFVTCRYRDY RYPPDHEDKY SHNMQFWHVL AAKMTFIIVM EHVVFLFKFL 841: LAWLIPDVPK DVVEKIKREK LMTIKIIHDF ELNKLKENLD VEYGNIMKNV LVDEDNSLKA 901: KTTV