1.A.17.1.22
Subdued, a calcium-activated chloride channel of 1075 aas. Functions in conjunction with the thermo-TRPs in thermal nociception. Subdued channels may amplify the nociceptive neuronal firing that is initiated by thermo-TRP channels in response to thermal stimuli (Jang et al. 2015). It may also act on phospholipids to transport or hydrolyze them (Le et al. 2019).
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| Accession Number: | Q9VDV4 |
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| Protein Name: | Anoctamin |
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| Length: | 1075 |
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| Molecular Weight: | 123935.00 |
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| Species: | Drosophila melanogaster (Fruit fly) [7227] |
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| Number of TMSs: | 8 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
chloride, phospholipid |
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1: MLNLGSAKVG ALEEATSPPP FSKDESFQLL ERSPHNPAIS PTTTVPLEPP FTTPLAPFDM
61: ELMKRHNLHE RLTGKESFWR GRDTSQRFLD QEQLSASRES LGAADKRARF AESNAPTLQL
121: PESAEPRANG KRPTGNRTNP SNPAAPLLPM TDPDFVKGNV GGVYDDRECS CPREFYQRGE
181: INTSLFFEDC VRSIDFVLAY RINAHEPTEL ENTEKRRVFE ANLISQGLEV ESSQKDQIWF
241: VKIHAPLEVL RRYAEILKLR MPMKEIPGMS VVNRSTKSVF SSLKHVFQFF LRNIYVDEEI
301: FPKRAHRFTA IYSRDKEYLF DIRQDCFFTT AVRSRIVEFI LDRQRFPAKN QHDMAFGIER
361: LIAEGVYSAA YPLHDGEITE TGTMRALLYK HWASVPKWYR YQPLDDIKEY FGVKIGLYFA
421: WLGYYTYMLL LASIVGVICF LYSWFSLKNY VPVKDICQSG NTNITMCPLC DWCNFWDLKE
481: TCNYAKVTYL IDNPSTVFFA VFMSFWATLF LELWKRYSAE ITHRWDLTGF DVHEEHPRPQ
541: YLARLEHIPP TRVDYVTNIK EPTVPFWRMK LPATVFSFSV VLLLIALAFV ALLAVVVYRM
601: SMLAALKVGA SPMTTSSAIV LATASAAFVN LCLLYILNYM YNHLAEYLTE LEMWRTQTQF
661: DDSLTLKIYL LQFVNYYASI FYIAFFKGKF VGHPGEYNKL FDYRQEECSS GGCLTELCIQ
721: LAIIMVGKQA FNTILEVYLP MFWRKVLAIQ VGLSRLFNNT PNPDKAKDER WMRDFKLLDW
781: GARGLFPEYL EMVLQYGFVT IFVAAFPLAP FFALLNNILE MRLDAKKLLT HHKRPVSQRV
841: RDIGVWYRIL DCIGKLSVIT NGFIIAFTSD MIPRLVYRHY VNKQGTLDGY LNFTLSEFKV
901: IDSPTLYSLA GDLSNITTCR YTDFRLPPSS PEKYTLSSMF YIILACRLGF VVVFENFVAL
961: VMILVRWCIP DMSVELRDQI RREVYVTNEI IIDQEAHRAR FERAKRSSSV LQTPVDQDMD
1021: AASIQEPNAK FINIEKLLTE NLTQIEMDAI IHGENPITGI SGADCLDEVH KKLSD